ArticleFrontiers in cardiovascular medicine2021
Left Ventricular Global Function Index and the Impact of its Companion Metric.
Article in Frontiers in cardiovascular medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed.
- Ejection Fraction in the Fast Lane.Echocardiography (Mount Kisco, N.Y.) · 2026Article
- Left Ventricular Global Function Index: A Potential Predictor of Mortality and Major Adverse Cardiovascular Events in NSTEMI Patients.Medicina (Kaunas, Lithuania) · 2025Article
- Cardiac ejection fraction as a problematic metric for heart failure phenotyping.The British journal of cardiology · 2024Article
- Inflammatory bowel disease and cardiac function: a systematic review of literature with meta-analysis.Therapeutic advances in gastroenterology · 2024Article
- Multiparametric analysis of coronary flow in psoriasis using a coronary flow reserve companion.European journal of clinical investigation · 2022Article
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2 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Left ventricular (LV) global function index (LVGFI) has been introduced as a volume-based composite metric for evaluation of ventricular function. The definition formula combines stroke volume (SV), end-systolic volume (ESV), end-diastolic volume (EDV) and LV mass/density. Being a dimensionless ratio, this new metric has serious limitations which require evaluation at a mathematical and clinical level. Using CMRI in 96 patients we studied LV volumes, various derived metrics and global longitudinal strain (GLS) in order to further characterize LVGFI in three diagnostic groups: acute myocarditis, takotsubo cardiomyopathy and acute myocardial infarction. We also considered the LVGFI companion (C), derived from the quadratic mean. Additional metrics such as ejection fraction (EF), myocardial contraction fraction (MCF) and ventriculo-arterial coupling (VAC), along with their companions (MCFC and VACC) were calculated. All companion metrics (EFC, LVGFIC, MCFC, and VACC) showed sex-specific differences, not clearly reflected by the corresponding ratio-based metrics. LVGFI is mathematically coupled to both EF (with R = 0.86) and VAC (R = 0.87), which observation clarifies why these metrics not only share similar prognostic values but also identical shortcomings. We found that the newly introduced LVGFIC has incremental value compared to the single use of LVGFI, EF, or GLS, when characterizing the three patient groups.
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