Evidence map›Paper›PMID 34527708›Full record

ArticleFrontiers in cardiovascular medicine2021

Radiation Induces Valvular Interstitial Cell Calcific Response in an

Manon Meerman, Rob Driessen, Nicole C A van Engeland, Irith Bergsma, Jacco L G Steenhuijsen, David Kozono, Elena Aikawa, Jesper Hjortnaes, Carlijn V C Bouten

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cardiovascular medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Models for calcific aortic valve disease in vivo and in vitro.Cell regeneration (London, England) · 2024
    Review
  5. Article
  6. Valvular Heart Disease Associated With Radiation Therapy: A Contemporary Review.Structural heart : the journal of the Heart Team · 2023
    Review
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Manon MeermanDepartment of Cardiothoracic Surgery, Heart and Lung Division, Leiden University Medical Center, Leiden, Netherlands.
Rob DriessenDepartment of Biomedical Engineering, Soft Tissue Engineering and Mechanobiology (STEM), Eindhoven University of Technology, Eindhoven, Netherlands.
Nicole C A van EngelandDepartment of Biomedical Engineering, Soft Tissue Engineering and Mechanobiology (STEM), Eindhoven University of Technology, Eindhoven, Netherlands.
Irith BergsmaDepartment of Biomedical Engineering, Soft Tissue Engineering and Mechanobiology (STEM), Eindhoven University of Technology, Eindhoven, Netherlands.
Jacco L G SteenhuijsenDepartment of Radiotherapy, Catherina Ziekenhuis Eindhoven, Eindhoven, Netherlands.
David KozonoDepartment of Radiation Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, United States.
Elena AikawaCenter for Interdisciplinary Cardiovascular Sciences, Cardiovascular Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States.
Jesper HjortnaesDepartment of Cardiothoracic Surgery, Heart and Lung Division, Leiden University Medical Center, Leiden, Netherlands.
Carlijn V C BoutenDepartment of Biomedical Engineering, Soft Tissue Engineering and Mechanobiology (STEM), Eindhoven University of Technology, Eindhoven, Netherlands.
Eindhoven University of Technology · NLLeiden University Medical Center · NLBrigham and Women's Hospital · USDana-Farber Cancer Institute · USRadboud University Nijmegen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

aortic valve diseaseextracellular matrixin vitro modelingradiotherapyvalvular interstitial cells

Identifiers

PMID34527708
PMCPMC8435633
OpenAlexW3196327690

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.