Evidence map›Paper›PMID 34527672›Full record

ReviewFrontiers in cell and developmental biology2021

Long Non-coding RNAs in Pathogenesis of Neurodegenerative Diseases.

Shiyue Zhou, Xiao Yu, Min Wang, Yujie Meng, Dandan Song, Hui Yang, Dewei Wang, Jianzhong Bi, Shunliang Xu

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.

  1. Pooled it
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  15. Regulatory Role of lncRNAInternational journal of molecular sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Shiyue ZhouDepartment of Neurology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
Xiao YuDepartment of Nutrition, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
Min WangDepartment of Neurology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
Yujie MengCheeloo College of Medicine, Shandong University, Jinan, China.
Dandan SongCheeloo College of Medicine, Shandong University, Jinan, China.
Hui YangDepartment of Neurology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
Dewei WangDepartment of Neurology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
Jianzhong BiDepartment of Neurology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
Shunliang XuDepartment of Neurology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
Second Hospital of Shandong University · CNShandong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Emerging evidence addresses the link between the aberrant epigenetic regulation of gene expression and numerous diseases including neurological disorders, such as Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), and Huntington's disease (HD). LncRNAs, a class of ncRNAs, have length of 200 nt or more, some of which crucially regulate a variety of biological processes such as epigenetic-mediated chromatin remodeling, mRNA stability, X-chromosome inactivation and imprinting. Aberrant regulation of the lncRNAs contributes to pathogenesis of many diseases, such as the neurological disorders at the transcriptional and post-transcriptional levels. In this review, we highlight the latest research progress on the contributions of some lncRNAs to the pathogenesis of neurodegenerative diseases

Indexed as

Alzheimer’s diseaseamyotrophic lateral sclerosisHuntington’s diseaselong non-coding RNAsneurodegenerative diseasesParkinson’s disease

Identifiers

PMID34527672
PMCPMC8435612
OpenAlexW3196453577

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.