Evidence map›Paper›PMID 34527552›Full record

ArticleGland surgery2021

Relationship between anti-acetylcholine receptor antibodies and the development of post-thymectomy myasthenia gravis in patients with thymoma: a single-center experience.

Yusuke Nabe, Teppei Hashimoto, Kanji Tanaka, Yasuhiro Fujita, Katsuma Yoshimatsu, Yukiko Nemoto, Rintaro Oyama, Hiroki Matsumiya, Masataka Mori, Masatoshi Kanayama and 7 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gland surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 1 institution in 1 country.

Yusuke NabeSecond Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Teppei HashimotoSecond Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Kanji TanakaSecond Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Yasuhiro FujitaSecond Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Katsuma YoshimatsuSecond Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Yukiko NemotoSecond Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Rintaro OyamaSecond Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Hiroki MatsumiyaSecond Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Masataka MoriSecond Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Masatoshi KanayamaSecond Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Akihiro TairaSecond Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Shinji ShinoharaSecond Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Taiji KuwataSecond Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Masaru TakenakaSecond Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Yuko TashimaSecond Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Koji KurodaSecond Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Fumihiro TanakaSecond Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
University of Occupational and Environmental Health Japan · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundApproximately 15-29.6% of patients with thymoma have myasthenia gravis (MG). Some of these patients develop MG after thymectomy despite having no history of MG or related symptoms. Few previous studies have examined the risk factors for the development of post-thymectomy MG in patients with thymoma. Herein, we retrospectively reviewed our institutional experience with patients with thymoma who developed MG after thymectomy.

methodsTwenty-six patients with thymoma but without MG, who were tested preoperatively for anti-acetylcholine receptor antibody (anti-AChR-Ab) levels, underwent surgical resection at our hospital between 2013 and 2020. Patients with thymic carcinoma were excluded from the study. We evaluated the association of outcomes with preoperative anti-AChR-Ab levels and post-thymectomy MG. We performed a χ

resultsThe characteristics of the 26 patients (median age: 62 years; 8 men, 18 women) were as follows: World Health Organization (WHO) classifications AB (n=8), B1 (n=9), B2 (n=6), B3 (n=1), and others (n=2) and Masaoka stage I (n=12), II (n=9), III (n=3), and IVa (n=2). Among the 26 patients, only five had high (>0.3 nmol/L) preoperative anti-AChR-Ab levels. Post-thymectomy MG occurred in two of the five patients (40%) with high preoperative anti-AChR-Ab levels. A high preoperative serum anti-AChR-Ab titer was significantly associated with post-thymectomy MG (P=0.0267). The anti-AChR-Ab titer was also measured postoperatively in four of the five (80%) patients with high preoperative levels. The anti-AChR-Ab titer decreased in two of these four patients, and neither developed postoperative MG.

conclusionsPreoperative and postoperative anti-AChR-Ab positivity might be associated with post-thymectomy MG. Therefore, regular measurement of anti-AChR-Ab levels after thymectomy is required.

Indexed as

anti-acetylcholine receptor antibody (anti-AChR-Ab)myasthenia gravis (MG)surgeryThymoma

Identifiers

PMID34527552
PMCPMC8411078
OpenAlexW3188098802

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.