Evidence map›Paper›PMID 34527426›Full record

ArticleJournal of clinical & cellular immunology2016

Arg Deficiency Does not Influence the Course of Myelin Oligodendrocyte Glycoprotein (MOG35-55)-induced Experimental Autoimmune Encephalomyelitis.

Freja Aksel Jacobsen, Camilla Hulst, Thomas Bäckström, Anthony J Koleske, Åsa Andersson

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical & cellular immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Freja Aksel JacobsenDepartment of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Camilla HulstDepartment of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Thomas BäckströmNovo Nordisk A/S, Måløv, Denmark.
Anthony J KoleskeDepartment of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven CT 06520, USA.
Åsa AnderssonDepartment of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
University of Copenhagen · DK

Funding

Roles of Abl and Arg Neuronal DevelopmentR01NS039475 · NINDS · YALE UNIVERSITY · PI KOLESKE, ANTHONY J · 2000 to 2012
$4.3M
Supplement to Regulation of invadopodia formation in breast cancer cellsR01CA133346 · NCI · YALE UNIVERSITY · PI KOLESKE, ANTHONY J · 2009 to 2016
$2.3M
Control of Dendritic Spine Stability via Regulation of a Stable Actin PoolR01MH115939 · NIMH · YALE UNIVERSITY · PI KOLESKE, ANTHONY J · 2018 to 2022
$2.2M
Laminin control of CNS dendrite and dendritic spine developmentR01NS089662 · NINDS · YALE UNIVERSITY · PI GRUTZENDLER, JAIME, KOLESKE, ANTHONY J · 2014 to 2018
$1.8M
The mechanism of Arg kinase activation by integrin B1R01GM100411 · NIGMS · YALE UNIVERSITY · PI BOGGON, TITUS JONATHON, KOLESKE, ANTHONY J · 2012 to 2015
$1.3M
NCI NIH HHS R01 CA133346NIGMS NIH HHS R01 GM100411NIMH NIH HHS R01 MH115939NINDS NIH HHS R01 NS039475NINDS NIH HHS R01 NS089662
6 · The paper itself

Abstract

backgroundInhibition of Abl kinases has an ameliorating effect on the rodent model for multiple sclerosis, experimental autoimmune encephalomyelitis, and arrests lymphocyte activation. The family of Abl kinases consists of the Abl1/Abl and Abl2/Arg tyrosine kinases. While the Abl kinase has been extensively studied in immune activation, roles for Arg are incompletely characterized. To investigate the role for Arg in experimental autoimmune encephalomyelitis, we studied disease development in Arg

methodsArg

resultsThe breeding of Arg

conclusionsDevelopment of MOG-induced experimental autoimmune encephalomyelitis is not dependent on Arg, but Arg plays a role for the number of B cells in immunized mice. This might suggest a novel role for the Arg kinase in B-cell trafficking or regulation. Furthermore, the results suggest that Arg is important for normal embryonic development.

Indexed as

Abelson related geneExperimental autoimmune encephalomyelitisGenotype frequencyLymphocyte phenotypes

Identifiers

PMID34527426
PMCPMC8439389
OpenAlexW2465798681

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.