Evidence map›Paper›PMID 34527334›Full record

ArticleJournal of thoracic disease2021

Utility of bronchoscopic intra-tumoral alcohol injection to restore airway patency.

Michael A Jantz, Mohamed Omballi, Bashar N Alzghoul, Sebastian Fernandez Bussy, David Becnel, Adnan Majid, Hiren J Mehta

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of thoracic disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Interventional bronchoscopy in lung cancer treatment.Breathe (Sheffield, England) · 2024
    Review
  2. Review
  3. Overview of malignant central airway obstruction.Mediastinum (Hong Kong, China) · 2023
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Michael A JantzPulmonary Medicine, North Florida Regional Medical Center, Gainesville, FL, USA.
Mohamed OmballiDivision of Pulmonary, Critical Care and Sleep Medicine, University of Florida, Gainesville, FL, USA.
Bashar N AlzghoulDivision of Pulmonary, Critical Care and Sleep Medicine, University of Florida, Gainesville, FL, USA.
Sebastian Fernandez BussyDivision of Pulmonary, Critical Care and Sleep Medicine, Mayo Clinic, Jacksonville, FL, USA.
David BecnelDivision of Pulmonary, Critical Care and Sleep Medicine, Tulane University, New Orleans, LA, USA.
Adnan MajidDivision of Pulmonary and Critical Care Medicine, Beth Israel Deaconess medical center, Boston, MA, USA.
Hiren J MehtaDivision of Pulmonary, Critical Care and Sleep Medicine, University of Florida, Gainesville, FL, USA.
University of Florida · USBeth Israel Deaconess Medical Center · USMayo Clinic in Florida · USRegional Medical Center · USTulane University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn cases of malignant airway obstruction, achieving airway patency using conventional bronchoscopic modalities can be challenging and may not be satisfactory. We aim to present our experience of using intra-tumoral alcohol injection (ITAI) to help achieve airway patency in malignant airway obstruction.

methodsA retrospective study of adult patients presenting with malignant airway obstruction who underwent bronchoscopy with ITAI at a university center between 2015 and 2020 was conducted. We present procedural and patients' characteristics along with any additional bronchoscopic or systemic interventions received. Patients were classified based on airway patency response (assessed qualitatively by an interventional pulmonologist) into those with good response (≥50% improvement in airway patency)

resultsForty-two patients underwent ITAI, of which 34 (81%) had at least two bronchoscopies to evaluate response. The patient median age was 65.5 [interquartile range (IQR) 57.8-72]. Most patients had stage IV malignancy at the time of the bronchoscopy (57.1%) and had Eastern Cooperative Oncology Group (ECOG) performance status score of between 2-3. Eighty-two percent of the patients achieved good airway patency response at the conclusion of the procedures. The procedures were generally well-tolerated and only one patient had significant bleeding that was not directly related to ITAI and required intensive care unit monitoring for 24 hours after the procedure.

conclusionsDehydrated alcohol is readily available, inexpensive and a safe drug that can be potentially injected directly in malignant airway obstructive lesions in a multimodality approach to achieve airway patency when traditional modalities reach their limitation. Further studies are warranted to determine whether ITAI is superior to other interventional methods, explore its utilization to treat peripheral malignant tumors, as well as to standardize the treatment protocol and determine the effects of ITAI on patient symptoms and quality of life.

Indexed as

airway obstructionalcoholBronchoscopylung cancermalignanttumor debulking

Identifiers

PMID34527334
PMCPMC8411124
OpenAlexW3191317504

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.