Evidence map›Paper›PMID 34527281›Full record

ArticleVirus evolution2021

Genomic epidemiology of SARS-CoV-2 transmission lineages in Ecuador.

Bernardo Gutierrez, Sully Márquez, Belén Prado-Vivar, Mónica Becerra-Wong, Juan José Guadalupe, Darlan Da Silva Candido, Juan Carlos Fernandez-Cadena, Gabriel Morey-Leon, Rubén Armas-Gonzalez, Derly Madeleiny Andrade-Molina and 28 more

Abstract read
In one paragraph

Article in Virus evolution, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

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  12. Feature selection reveal peripheral blood parameter's changes between COVID-19 infections patients from Brazil and Ecuador.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2022
    Article
  13. Review
  14. Article
  15. Occurrence of SARS-CoV-2 reinfections at regular intervals in Ecuador.Frontiers in cellular and infection microbiology · 2022
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

38 authors.

Bernardo GutierrezDepartment of Zoology, University of Oxford, Oxford, Oxfordshire OX1 3SY, UK.ORCID https://orcid.org/0000-0002-9220-2739
Sully MárquezInstituto de Microbiología, Universidad San Francisco de Quito, Quito 170901, Ecuador.
Belén Prado-VivarInstituto de Microbiología, Universidad San Francisco de Quito, Quito 170901, Ecuador.
Mónica Becerra-WongInstituto de Microbiología, Universidad San Francisco de Quito, Quito 170901, Ecuador.
Juan José GuadalupeLaboratorio de Biotecnología Vegetal, Universidad San Francisco de Quito, Quito 170901, Ecuador.
Darlan Da Silva CandidoDepartment of Zoology, University of Oxford, Oxford, Oxfordshire OX1 3SY, UK.
Juan Carlos Fernandez-CadenaOmics Sciences Laboratory, Faculty of Medical Sciences, Universidad de Especialidades Espíritu Santo, Samborondón 092301, Ecuador.
Gabriel Morey-LeonFaculty of Medical Sciences, Universidad de Guayaquil, Guayaquil 090613, Ecuador.
Rubén Armas-GonzalezFaculty of Sciences, Escuela Superior Politécnica del Litoral, Guayaquil 090112, Ecuador.
Derly Madeleiny Andrade-MolinaOmics Sciences Laboratory, Faculty of Medical Sciences, Universidad de Especialidades Espíritu Santo, Samborondón 092301, Ecuador.
Alfredo BrunoInstituto Nacional de Investigación en Salud Pública, Guayaquil 3961, Ecuador.
Domenica De MoraInstituto Nacional de Investigación en Salud Pública, Guayaquil 3961, Ecuador.
Maritza OlmedoInstituto Nacional de Investigación en Salud Pública, Guayaquil 3961, Ecuador.
Denisse PortugalInstituto Nacional de Investigación en Salud Pública, Guayaquil 3961, Ecuador.
Manuel GonzalezInstituto Nacional de Investigación en Salud Pública, Guayaquil 3961, Ecuador.
Alberto OrlandoInstituto Nacional de Investigación en Salud Pública, Guayaquil 3961, Ecuador.
Jan Felix DrexlerInstitute of Virology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin 10117, Germany.ORCID https://orcid.org/0000-0002-3509-0232
Andres Moreira-SotoInstitute of Virology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin 10117, Germany.
Anna-Lena SanderInstitute of Virology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin 10117, Germany.
Sebastian BrüninkInstitute of Virology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin 10117, Germany.
Arne KühneInstitute of Virology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin 10117, Germany.
Leandro PatiñoInstituto Nacional de Investigación en Salud Pública, Guayaquil 3961, Ecuador.
Andrés Carrazco-MontalvoInstituto Nacional de Investigación en Salud Pública, Quito 170403, Ecuador.
Orson MestanzaServicio de Genética, Instituto Nacional de Salud del Niño San Borja, Lima 15037, Perú.ORCID https://orcid.org/0000-0001-7268-0496
Jeannete ZuritaFacultad de Medicina, Pontificia Universidad Católica del Ecuador, Quito 170143, Ecuador.
Gabriela SevillanoUnidad de Investigaciones en Biomedicina, Zurita & Zurita Laboratorios, Quito 170104, Ecuador.
Louis Du PlessisDepartment of Zoology, University of Oxford, Oxford, Oxfordshire OX1 3SY, UK.
John T McCroneInstitute of Evolutionary Biology, University of Edinburgh, Edinburgh EH9 3JW, UK.
Josefina ColomaSchool of Public Health, University of California, Berkeley CA 94704, USA.
Gabriel TruebaInstituto de Microbiología, Universidad San Francisco de Quito, Quito 170901, Ecuador.
Verónica BarragánInstituto de Microbiología, Universidad San Francisco de Quito, Quito 170901, Ecuador.
Patricio Rojas-SilvaInstituto de Microbiología, Universidad San Francisco de Quito, Quito 170901, Ecuador.ORCID https://orcid.org/0000-0002-9611-3661
Michelle GrunauerEscuela de Medicina, Universidad San Francisco de Quito, Quito 170901, Ecuador.
Moritz U G KraemerDepartment of Zoology, University of Oxford, Oxford, Oxfordshire OX1 3SY, UK.
Nuno R FariaDepartment of Zoology, University of Oxford, Oxford, Oxfordshire OX1 3SY, UK.
Marina Escalera-ZamudioDepartment of Zoology, University of Oxford, Oxford, Oxfordshire OX1 3SY, UK.
Oliver G PybusDepartment of Zoology, University of Oxford, Oxford, Oxfordshire OX1 3SY, UK.ORCID https://orcid.org/0000-0002-8797-2667
Paúl CárdenasInstituto de Microbiología, Universidad San Francisco de Quito, Quito 170901, Ecuador.

Funding

Research Mentoring and Building Capacity of underrepresented Minority Research Scientists in India.D43TW010540 · FIC · YALE UNIVERSITY · PI MICHELE BARRY, Eva Harris · 2017 to 2026
$15.5M
American Asian Centers for Arbovirus Research and Enhanced Surveillance (A2CARES)U01AI151788 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI Josefina Coloma, Eva Harris · 2020 to 2026
$9.6M
FIC NIH HHS D43 TW010540Medical Research Council MC_PC_19012Medical Research Council MR/R015600/1Medical Research Council MR/S019510/1NIAID NIH HHS U01 AI151788
6 · The paper itself

Abstract

Characterisation of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) genetic diversity through space and time can reveal trends in virus importation and domestic circulation and permit the exploration of questions regarding the early transmission dynamics. Here, we present a detailed description of SARS-CoV-2 genomic epidemiology in Ecuador, one of the hardest hit countries during the early stages of the coronavirus-19 pandemic. We generated and analysed 160 whole genome sequences sampled from all provinces of Ecuador in 2020. Molecular clock and phylogeographic analysis of these sequences in the context of global SARS-CoV-2 diversity enable us to identify and characterise individual transmission lineages within Ecuador, explore their spatiotemporal distributions, and consider their introduction and domestic circulation. Our results reveal a pattern of multiple international importations across the country, with apparent differences between key provinces. Transmission lineages were mostly introduced before the implementation of non-pharmaceutical interventions, with differential degrees of persistence and national dissemination.

Indexed as

molecular epidemiologyphylogeneticsphylogeographySARS-CoV-2transmission lineages

Identifiers

PMID34527281
PMCPMC8244811

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.