Evidence map›Paper›PMID 34527241›Full record

ArticleAnnals of medicine and surgery (2012)2021

Managing misdiagnosed gingival squamous cell carcinoma (GSCC) with occult symptoms: A report of two cases.

Fatima Alzhra Hanifa, Aya Zazo, Mohammad Kamel Fares, Mohamad AlHashemi, Bashar Bazkke, Bakr Haddad, Ammar Niazi

Open access · diamondAbstract readCase Reports
In one paragraph

Article in Annals of medicine and surgery (2012), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 78% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. FASEB bioAdvances · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Fatima Alzhra HanifaFaculty of Medicine, University of Aleppo, Aleppo, Syria.
Aya ZazoFaculty of Medicine, University of Aleppo, Aleppo, Syria.
Mohammad Kamel FaresAleppo University Hospital, Aleppo, Syria.
Mohamad AlHashemiFaculty of Medicine, University of Aleppo, Aleppo, Syria.
Bashar BazkkeFaculty of Medicine, University of Aleppo, Aleppo, Syria.
Bakr HaddadOral and Maxillofacial Surgery Department, Aleppo University Hospital, Aleppo, Syria.
Ammar NiaziGeneral Surgery Department, Faculty of Medicine, Aleppo University Hospital, Aleppo, Syria.
University of Aleppo · SY

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionimportance: Gingival squamous cell carcinoma (GSCC) is a rare neoplasm. GSCC has nonspecific features which commonly misdiagnosed with a simple toothache. CASE PRESENTATION: These are two cases; the first one describes a 62-year-old female who presented with pain in her right posterior mandibular teeth, and she was misdiagnosed with periodontal disease, but later histopathological tests confirmed gingival squamous cell carcinoma (GSCC). Consequently, the patient underwent surgery, and the gingival tumor was totally resected. Afterward, the patient was receiving chemotherapy, and the radiotherapy was postponed until the chemotherapy completion.The second case is of a 58-year-old female who presented with pain in her mandibular incisors, and she developed a dermal fistula on her chin and therefore underwent several gingival curettages. The following histopathologic tests confirmed GSCC so she underwent surgery, after the surgery it was planned to give her chemotherapy. CLINICAL DISCUSSION: GSCC is a rare neoplasm with a 6% incidence of all oral malignancies. GSCC is a very challenging cancer for a physician or a pathologist to diagnose because GSCC usually mimics the characteristics of a large variety of diseases and abnormalities. Unlike oral neoplasms, GSCC has the least association with smoking. This may lead to make mistakes in the treatment or misdiagnose it until the late-stage of GSCC.

conclusionDespite the rare incidence of Gingival squamous cell carcinoma (GSCC), clinicians should consider GSCC while investigating any localized lesion with nonspecific oral symptoms.

Indexed as

Case reportGingival squamous cell carcinoma (GSCC)Head and neck surgeryMandibular neoplasmsOral cancer

Identifiers

PMID34527241
PMCPMC8429914
OpenAlexW3196674662

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.