Evidence map›Paper›PMID 34527185›Full record

ArticleComputational and structural biotechnology journal2021

Magnesium ions regulate mesenchymal stem cells population and osteogenic differentiation: A fuzzy agent-based modeling approach.

Jalil Nourisa, Berit Zeller-Plumhoff, Heike Helmholz, Bérengère Luthringer-Feyerabend, Vladimir Ivannikov, Regine Willumeit-Römer

Open access · goldAbstract read
In one paragraph

Article in Computational and structural biotechnology journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jalil NourisaHelmholtz Zentrum Hereon, Institute of Metallic Biomaterials, Max-Planck-Straße 1, 21502 Geesthacht, Germany.
Berit Zeller-PlumhoffHelmholtz Zentrum Hereon, Institute of Metallic Biomaterials, Max-Planck-Straße 1, 21502 Geesthacht, Germany.
Heike HelmholzHelmholtz Zentrum Hereon, Institute of Metallic Biomaterials, Max-Planck-Straße 1, 21502 Geesthacht, Germany.
Bérengère Luthringer-FeyerabendHelmholtz Zentrum Hereon, Institute of Metallic Biomaterials, Max-Planck-Straße 1, 21502 Geesthacht, Germany.
Vladimir IvannikovHelmholtz Zentrum Hereon, Institute of Metallic Biomaterials, Max-Planck-Straße 1, 21502 Geesthacht, Germany.
Regine Willumeit-RömerHelmholtz Zentrum Hereon, Institute of Metallic Biomaterials, Max-Planck-Straße 1, 21502 Geesthacht, Germany.
Helmholtz-Zentrum Hereon · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mesenchymal stem cells (MSCs) are proliferative and multipotent cells that play a key role in the bone regeneration process. Empirical data have repeatedly shown the bioregulatory importance of magnesium (Mg) ions in MSC growth and osteogenesis. In this study, we propose an agent-based model to predict the spatiotemporal dynamics of the MSC population and osteogenic differentiation in response to Mg

Indexed as

Agent-based simulationApproximate Bayesian calculationCell populationFuzzy logic-based approachMagnesium ionsMesenchymal stem cellsOsteogenic differentiation

Identifiers

PMID34527185
PMCPMC8346546
OpenAlexW3180863040

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.