Evidence map›Paper›PMID 34527182›Full record

ArticleJournal of oral microbiology2021

Mycotic infections - mucormycosis and oral candidiasis associated with Covid-19: a significant and challenging association.

Manjusha Nambiar, Sudhir Rama Varma, Mohamed Jaber, S V Sreelatha, Biju Thomas, Arathi S Nair

Abstract read
In one paragraph

Article in Journal of oral microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Post-COVID-19 Jaw Osteonecrosis: A Narrative Review.Medicina (Kaunas, Lithuania) · 2026
    Review
  3. Review
  4. Article
  5. Article
  6. Fungal biofilms in human health and disease.Nature reviews. Microbiology · 2025
    Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Oral Mycobiome and COVID-19.Microorganisms · 2023
    Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Manjusha NambiarDepartment of Periodontics, College of Dentistry, Sri Rajiv Gandhi, College of Dental Sciences and Hospital, Benguluru, India.ORCID https://orcid.org/0000-0002-9791-0558
Sudhir Rama VarmaDepartment of Clinical Sciences, College of Dentistry, Ajman University, Ajman, UAE.ORCID https://orcid.org/0000-0001-6793-9344
Mohamed JaberDepartment of Oral and Maxillofacial Surgery, College of Dentistry, Ajman University, Ajman, UAE.ORCID https://orcid.org/0000-0002-5524-5131
S V SreelathaDepartment of Oral Pathology, College of Dentistry, Ab Shetty Institute of Dental Sciences- (Nitte to Be Deemed University), Manguluru, India.ORCID https://orcid.org/0000-0002-8847-9372
Biju ThomasDepartment of Periodontics, College of Dentistry, Ab Shetty Institute of Dental Sciences- (Nitte to Be Deemed University), Manguluru, India.ORCID https://orcid.org/0000-0001-8908-1019
Arathi S NairDepartment of Conservative Dentistry & Endodontics, Sri Rajiv Gandhi College of Dental Sciences and Hospital, Benguluru, India.ORCID https://orcid.org/0000-0003-2554-0559

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionBacterial and fungal secondary infections following COVID-19 disease are widely being reported and are an area that should receive careful attention. Mucormycosis is a fatal fungal condition affecting immunocompromised patients caused by a group of mold mucoromycetes. MATERIALS AND

methodsArticles were taken from a period of 2020 to April 2021 using search sources such as Cochrane, PubMed, Fungiscope and Mycobank using keywords mucormycosis, Black fungus, oral candidiasis, white fungus, COVID-19, Sars-Cov-2. DISCUSSION: The development of oral mucocutaneous lesions, such as mucormycosis and candidiasis in COVID-19 patients could be due to inhaling spores resulting in pulmonary and/or sinus congestion and prolonged mechanical ventilation in the ICU settings and the long-term use of broad-spectrum antibiotics respectively. The onset of candidiasis after the emergence of COVID-19 clinical signs and symptoms varied considerably and is reported within 1-30 days in most of the cases reported in the literature. Biofilms present on the denture surfaces are predisposing factors to oral candidiasis. We aim to summarize the limited data available regarding diagnosis, clinical presentation, and therapeutic approaches for the management of Mucormycosis and oral candidiasis in COVID-19 patients.

conclusionCareful monitoring of oral lesions should be instituted through interdisciplinary telemedicine and teleconsultation to aid in primary diagnosis, thereby avoiding personal attendance during the pandemic. Dental practitioners should be included among the interdisciplinary teams for exhaustive intraoral examination and reduce the risk of morbidity and mortality.

Indexed as

black funguscovid-19MucormycosisOral candidiasissars-coV-2white fungus

Identifiers

PMID34527182
PMCPMC8436966

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.