Evidence map›Paper›PMID 34527175›Full record

ArticleOxidative medicine and cellular longevity2021

Genetic Association in the Maintenance of the Mitochondrial Microenvironment and Sperm Capacity.

Hwang I S Thomas, Ying-Shiuan Chen, Ching-Han Hung, Dilip Bhargava Sreerangaraja Urs, Tien-Ling Liao, Yen-Chun Lai, Katerina Komrskova, Pavla Postlerová, Yung-Feng Lin, Shu-Huei Kao

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PubMed Full text at PMC Publisher
In one paragraph

Article in Oxidative medicine and cellular longevity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
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  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 2 countries.

Hwang I S ThomasDivision of Urology, Department of Surgery, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.ORCID https://orcid.org/0000-0003-1062-6640
Ying-Shiuan ChenSchool of Medical Laboratory Science and Biotechnology, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.ORCID https://orcid.org/0000-0003-2229-3003
Ching-Han HungSchool of Medical Laboratory Science and Biotechnology, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.ORCID https://orcid.org/0000-0002-4253-1788
Dilip Bhargava Sreerangaraja UrsPh.D. Program in Medical Biotechnology, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.ORCID https://orcid.org/0000-0003-1989-8749
Tien-Ling LiaoSchool of Medical Laboratory Science and Biotechnology, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.ORCID https://orcid.org/0000-0001-6586-2427
Yen-Chun LaiSchool of Medical Laboratory Science and Biotechnology, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.ORCID https://orcid.org/0000-0002-4703-5708
Katerina KomrskovaLaboratory of Reproductive Biology, Institute of Biotechnology of the Czech Academy of Sciences (BIOCEV), Vestec, Czech Republic.ORCID https://orcid.org/0000-0002-6837-2148
Pavla PostlerováLaboratory of Reproductive Biology, Institute of Biotechnology of the Czech Academy of Sciences (BIOCEV), Vestec, Czech Republic.ORCID https://orcid.org/0000-0002-5090-4652
Yung-Feng LinSchool of Medical Laboratory Science and Biotechnology, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.ORCID https://orcid.org/0000-0003-3165-9177
Shu-Huei KaoSchool of Medical Laboratory Science and Biotechnology, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.ORCID https://orcid.org/0000-0003-4618-0898
Taipei Medical University · TWCharles University · CZCzech University of Life Sciences Prague · CZFu Jen Catholic University · TWTaipei City Hospital · TWTaipei Medical University Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sperm motility is one of the major determinants of male fertility. Since sperm need a great deal of energy to support their fast movement by active metabolism, they are thus extremely vulnerable to oxidative damage by the reactive oxygen species (ROS) and other free radicals generated as byproducts in the electron transport chain. The present study is aimed at understanding the impact of a mitochondrial oxidizing/reducing microenvironment in the etiopathology of male infertility. We detected the mitochondrial DNA (mtDNA) 4,977 bp deletion in human sperm. We examined the gene mutation of ATP synthase 6 (

Indexed as

DNA GlycosylasesDNA, MitochondrialGene FrequencyHumansHydrogen PeroxideInfertility, MaleMaleMembrane Potential, MitochondrialMitochondriaOxidative StressPolymorphism, GeneticSpermatozoaSperm MotilitySuperoxide DismutaseUncoupling Protein 2DNA GlycosylasesDNA, MitochondrialHydrogen Peroxideoxoguanine glycosylase 1, humanSuperoxide DismutaseUCP2 protein, humanUncoupling Protein 2

Identifiers

PMID34527175
PMCPMC8437596
OpenAlexW3197438265

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.