Evidence map›Paper›PMID 34527031›Full record

ArticleJournal of geriatric cardiology : JGC2021

Prognostic relevance of normocytic anemia in elderly patients affected by cardiovascular disease.

Liana Spazzafumo, Fabiola Olivieri, Jacopo Sabbatinelli, Roberta Galeazzi, Rina Recchioni, Fiorella Marcheselli, Paola Tamburrini, Roberto Antonicelli

Open access · greenAbstract read
In one paragraph

Article in Journal of geriatric cardiology : JGC, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Liana SpazzafumoEpidemiologic Observatory, Regional Health Agency, Regione Marche, Ancona, Italy.
Fabiola OlivieriDepartment of Clinical and Molecular Sciences, Università Politecnica delle Marche, Ancona, Italy.
Jacopo SabbatinelliDepartment of Clinical and Molecular Sciences, Università Politecnica delle Marche, Ancona, Italy.
Roberta GaleazziClinical Laboratory and Molecular Diagnostic, Italian National Research Center on Aging, IRCCS INRCA, Ancona, Italy.
Rina RecchioniCenter of Clinical Pathology and Innovative Therapy, Italian National Research Centre on Aging, IRCCS INRCA, Ancona, Italy.
Fiorella MarcheselliCenter of Clinical Pathology and Innovative Therapy, Italian National Research Centre on Aging, IRCCS INRCA, Ancona, Italy.
Paola TamburriniDepartment of Cardiology-CCU, Italian National Research Centre on Aging, IRCCS INRCA, Ancona, Italy.
Roberto AntonicelliDepartment of Cardiology-CCU, Italian National Research Centre on Aging, IRCCS INRCA, Ancona, Italy.
Istituto Nazionale di Riposo e Cura per Anziani · ITAgenzia Regionale per la Protezione Ambientale del Piemonte · ITAzienda Ospedaliero Universitaria Ospedali Riuniti · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAnemia associated with cardiovascular diseases (CVD) is a common condition in older persons. Prevalence and prognostic role of anemia were extensively studied in patients with myocardial infarction (MI) or congestive heart failure (CHF) whereas limited data were available on patients with atrial fibrillation (AF). This study was conducted to assess the clinical prevalence and prognostic relevance of anemia in elderly patients affected by AF and other CVDs.

methodsA total of 866 elderly patients (430 men and 436 women, age: 65-98 years, mean age: 85 ± 10 years) were enrolled. Among these patients, 267 patients had acute non-ST-segment elevation MI (NSTEMI), 176 patients had acute CHF, 194 patients had acute AF and 229 patients were aged-matched healthy persons (CTR). All parameters were measured at the hospital admission and cardiovascular mortality was assessed during twenty-four months of follow-up.

resultsThe prevalence of anemia was higher in NSTEMI, CHF and AF patients compared to CTR subjects (50%

conclusionsThe significant associations between CVD and anemia and the prognostic relevance of anemia for elderly patients with CVD were confirmed in this study. The presence of anemia in AF patients is associated with a two-fold increased mortality risk compared with non-anemic AF patients. Low hemoglobin and high reticulocyte count independently predict mortality in elderly patients with CVD.

Identifiers

PMID34527031
PMCPMC8390933
OpenAlexW3196163783

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.