Evidence map›Paper›PMID 34527027›Full record

ArticleJournal of geriatric cardiology : JGC2021

Impact of statin intensity on adverse cardiac and cerebrovascular events in older adult patients with myocardial infarction.

In Tae Moon, Si-Hyuck Kang, Wonjae Lee, Youngjin Cho, Jin Joo Park, Yeonyee E Yoon, Il-Young Oh, Chang-Hwan Yoon, Jung-Won Suh, Tae-Jin Youn and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of geriatric cardiology : JGC, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact, top 83% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 1 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

In Tae MoonUijeongbu Eulji Medical Center, Eulji University School of Medicine, Uijeongbu, South Korea.
Si-Hyuck KangSeoul National University Bundang Hospital, Seongnam, South Korea.
Wonjae LeeSeoul National University Bundang Hospital, Seongnam, South Korea.
Youngjin ChoSeoul National University Bundang Hospital, Seongnam, South Korea.
Jin Joo ParkSeoul National University Bundang Hospital, Seongnam, South Korea.
Yeonyee E YoonSeoul National University Bundang Hospital, Seongnam, South Korea.
Il-Young OhSeoul National University Bundang Hospital, Seongnam, South Korea.
Chang-Hwan YoonSeoul National University Bundang Hospital, Seongnam, South Korea.
Jung-Won SuhSeoul National University Bundang Hospital, Seongnam, South Korea.
Tae-Jin YounSeoul National University Bundang Hospital, Seongnam, South Korea.
In-Ho ChaeSeoul National University Bundang Hospital, Seongnam, South Korea.
Dong-Ju ChoiSeoul National University Bundang Hospital, Seongnam, South Korea.
Young-Seok ChoDepartment of Cardiology, Incheon Sejong Hospital, Incheon, South Korea.
Seoul National University Bundang Hospital · KREulji University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThere is insufficient evidence regarding the effect of high-intensity statin therapy in older adults. This study aimed to investigate the effects of high-intensity statin treatment on the clinical outcomes in older adults with myocardial infarction (MI).

methodsConsecutive patients with MI aged at least 75 years were analyzed retrospectively. The primary endpoint was major adverse cardiac and cerebrovascular events (MACCE), defined as a composite of all-cause death, MI, rehospitalization due to unstable angina, repeat revascularization, and ischemic stroke. The high-intensity group was compared to the low-to-moderate intensity group in the propensity score-matched cohort.

resultsAverage age of total 546 patients was 81 years. Among them, 84% of patients underwent percutaneous coronary intervention. The unadjusted seven-year MACCE rate differed by statin intensity (high-intensity statin group: 38%, moderate-intensity statin group: 42%, low-intensity statin group: 56%, and no-statin group: 61%,

conclusionsIn older adult patients with MI, the use of high-intensity statin caused significantly less occurrence of MACCE in comparison to that in low-to-moderate intensity for up to seven years of follow-up.

Identifiers

PMID34527027
PMCPMC8390935
OpenAlexW3194530007

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.