ArticleFrontiers in genetics2021
No Casual Relationship Between T2DM and the Risk of Infectious Diseases: A Two-Sample Mendelian Randomization Study.
Article in Frontiers in genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- Inflammatory bowel disease and risk of coronary heart disease : A Mendelian randomization study.Wiener klinische Wochenschrift · 2022Pooled it
- Obstructive sleep apnea's causal links to depression, well-being, and negative moods: a bidirectional mendelian randomized study.European archives of psychiatry and clinical neuroscience · 2026Article
- The interplay between type 2 diabetes mellitus and sepsis: a scoping review.International journal of medical sciences · 2026Article
- Type 2 diabetes and cause-specific mortality in Mexico City: a Mendelian randomisation analysis.Lancet regional health. Americas · 2025Article
- Exploring and validating associations between six systemic inflammatory indices and ischemic stroke in a middle-aged and old Chinese population.Aging clinical and experimental research · 2025Article
- A Genome-wide Association Study of Susceptibility to Upper Urinary Tract Infections.The Journal of infectious diseases · 2024Article
- Exploring the causal role of the immune response to varicella-zoster virus on multiple traits: a phenome-wide Mendelian randomization study.BMC medicine · 2023Article
- Causal relationship between type 1 diabetes mellitus and six high-frequency infectious diseases: A two-sample mendelian randomization study.Frontiers in endocrinology · 2023Article
- Article
- Editorial: Advances in genomic and genetic tools, and their applications for understanding embryonic development and human diseases.Frontiers in cell and developmental biology · 2022Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn epidemiological studies, it has been proven that the occurrence of type 2 diabetes mellitus (T2DM) is related to an increased risk of infectious diseases. However, it is still unclear whether the relationship is casual.
methodsWe employed a two-sample Mendelian randomization (MR) to clarify the causal effect of T2DM on high-frequency infectious diseases: sepsis, skin and soft tissue infections (SSTIs), urinary tract infections (UTIs), pneumonia, and genito-urinary infection (GUI) in pregnancy. And then, we analyzed the genome-wide association study (GWAS) meta-analysis of European-descent individuals and conducted T2DM-related single-nucleotide polymorphisms (SNPs) as instrumental variables (IVs) that were associated with genome-wide significance (
resultsThe UK Biobank (UKB) cohort (
conclusionT2DM would not be causally associated with high-frequency infectious diseases (including sepsis, SSTI, UTI, pneumonia, and GUI in pregnancy).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.