ArticleFrontiers in genetics2021
Association of Genetic Variants Affecting microRNAs and Pancreatic Cancer Risk.
Open access · goldAbstract read
In one paragraph
Article in Frontiers in genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 18% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Polymorphisms within autophagy-related genes as susceptibility biomarkers for pancreatic cancer: A meta-analysis of three large European cohorts and functional characterization.International journal of cancer · 2025Pooled it
- Review
- Detection of mutated KRAS, TP53, CDKN2A, and SMAD4 in tumor cell-free DNA of Brazilian pancreatic adenocarcinoma patients using next-generation sequencing.Scientific reports · 2026Article
- Polymorphisms in transcription factor binding sites and enhancer regions and pancreatic ductal adenocarcinoma risk.Human genomics · 2024Article
- Circulating Cell-Free Nucleic Acids as Biomarkers for Diagnosis and Prognosis of Pancreatic Cancer.Biomedicines · 2023Review
- Role of pancreatic ductal adenocarcinoma risk factors in intraductal papillary mucinous neoplasm progression.Frontiers in oncology · 2023Article
- Clustering analysis revealed the autophagy classification and potential autophagy regulators' sensitivity of pancreatic cancer based on multi-omics data.Cancer medicine · 2023Article
- Genetic Susceptibility in Understanding of Pancreatic Ductal Adenocarcinoma Risk: A Decade-Long Effort of the PANDORA Consortium.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
77 authors at 20 institutions in 12 countries.
Ye LuGenomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Chiara CorradiDepartment of Biology, University of Pisa, Pisa, Italy.
Manuel GentiluomoDepartment of Biology, University of Pisa, Pisa, Italy.
Evangelina López de MaturanaGenetic and Molecular Epidemiology Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
George E TheodoropoulosFirst Propaedeutic University Surgery Clinic, Hippocratio General Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Susanne RothDepartment of General Surgery, University of Heidelberg, Heidelberg, Germany.
Evaristo MaielloDepartment of Oncology, Fondazione IRCCS "Casa Sollievo della Sofferenza" Hospital, San Giovanni Rotondo, Italy.
Luca MorelliGeneral Surgery, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.
Livia ArchibugiDigestive and Liver Disease Unit, Sant'Andrea Hospital, Rome, Italy.
Jakob R IzbickiDepartment of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Patricia SarlósFirst Department of Medicine, Medical School, University of Pécs, Pécs, Hungary.
Vytautas KiudelisDepartment of Gastroenterology, Institute for Digestive Research, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Martin OliveriusDepartment of Surgery, Faculty Hospital Kralovske Vinohrady and Third Faculty of Medicine, Charles University, Prague, Czechia.
Mateus Nóbrega AokiLaboratory for Applied Science and Technology in Health, Carlos Chagas Institute, Curitiba, Brazil.
Yogesh VashistDepartment of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Casper H J van EijckDepartment of Surgery, Erasmus Medical Center, Erasmus University, Rotterdam, Netherlands.
Maria GazouliLaboratory of Biology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Renata Talar-WojnarowskaDepartment of Digestive Tract Diseases, Medical University of Lodz, Lodz, Poland.
Andrea MambriniOncological Department, Azienda USL Toscana Nord Ovest, Oncological Unit of Massa Carrara, Carrara, Italy.
Raffaele PezzilliDepartment of Gastroenterology, San Carlo Hospital, Potenza, Italy.
Bas Bueno-de-MesquitaDepartment for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands.
Péter HegyiInstitute for Translational Medicine, Medical School, University of Pécs, Pécs, Hungary.
Pavel SoučekBiomedical Center, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czechia.
John P NeoptolemosDepartment of General Surgery, University of Heidelberg, Heidelberg, Germany.
Gregorio Di FrancoGeneral Surgery, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.
Cosimo SpertiDepartment of Surgery-DiSCOG, Padua University Hospital, Padua, Italy.
Emanuele F KauffmannDivision of General and Transplant Surgery, University of Pisa, Pisa, Italy.
Viktor HlaváčBiomedical Center, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czechia.
Faik G UzunoğluDepartment of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Stefano ErminiBlood Transfusion Service, Azienda Ospedaliero-Universitaria Meyer, Children's Hospital, Florence, Italy.
Ewa Małecka-PanasDepartment of Digestive Tract Diseases, Medical University of Lodz, Lodz, Poland.
Maurizio LucchesiOncological Department, Azienda USL Toscana Nord Ovest, Oncological Unit of Massa Carrara, Carrara, Italy.
Giuseppe VanellaDigestive and Liver Disease Unit, Sant'Andrea Hospital, Rome, Italy.
Frederike DijkDeparment of Pathology, Cancer Center Amsterdam, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Netherlands.
Beatrice Mohelníková-DuchoňováDepartment of Oncology, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, Olomouc, Czechia.
Franco BambiBlood Transfusion Service, Azienda Ospedaliero-Universitaria Meyer, Children's Hospital, Florence, Italy.
Maria Chiara PetronePancreato-Biliary Endoscopy and Endosonography Division, Pancreas Translational and Clinical Research Center, IRSSC San Raffaele Scientific Institute, Milan, Italy.
Krzysztof JamroziakDepartment of Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland.
Feng GuoMedical Faculty Heidelberg, University of Heidelberg, Heidelberg, Germany.
Katerina KolarovaDepartment of Oncology, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, Olomouc, Czechia.
Giovanni CaprettiDepartment of Biomedical Sciences, Humanitas University, Milan, Italy.
Anna Caterina MilanettoDepartment of Surgery-DiSCOG, Padua University Hospital, Padua, Italy.
Laura GinocchiOncological Department, Azienda USL Toscana Nord Ovest, Oncological Unit of Massa Carrara, Carrara, Italy.
Martin LovečekDepartment of Surgery I, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, Olomouc, Czechia.
Marta PuzzonoDivision of Experimental Oncology, Gastroenterology and Gastrointestinal Endoscopy Unit, Vita-Salute San Raffaele University, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Hanneke W M van LaarhovenDepartment of Medical Oncology, Cancer Center Amsterdam, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands.
Silvia CarraraDivision of Gastroenterology and Digestive Endoscopy, Department of Gastroenterology, Humanitas Clinical and Research Center IRCCS, Milan, Italy.
Audrius IvanauskasDepartment of Gastroenterology, Institute for Digestive Research, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Konstantinos PapirisEndoscopic Surgery Department, Hippocratio General Hospital of Athens, Athens, Greece.
Daniela BassoDepartment of Medicine-DIMED, Padua University Hospital, Padua, Italy.
Paolo G ArcidiaconoPancreato-Biliary Endoscopy and Endosonography Division, Pancreas Translational and Clinical Research Center, IRSSC San Raffaele Scientific Institute, Milan, Italy.
Ferenc IzbékiSzent György University Teaching Hospital of County Fejér, Székesfehérvár, Hungary.
Roger ChammasDepartment of Radiology and Oncology, Institute of Cancer of São Paulo (ICESP), São Paulo, Brazil.
Pavel VodickaDepartment of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czechia.
Thilo HackertDepartment of General Surgery, University of Heidelberg, Heidelberg, Germany.
Claudio PasqualiDepartment of Surgery-DiSCOG, Padua University Hospital, Padua, Italy.
Maria L PireddaARC-NET, Centre for Applied Research on Cancer, University and Hospital Trust of Verona, Verona, Italy.
Eithne Costello-GoldringDepartment of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool, United Kingdom.
Giulia Martina CavestroDivision of Experimental Oncology, Gastroenterology and Gastrointestinal Endoscopy Unit, Vita-Salute San Raffaele University, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Andrea SzentesiInstitute for Translational Medicine, Medical School, University of Pécs, Pécs, Hungary.
Francesca TavanoDivision of Gastroenterology and Research Laboratory, Fondazione IRCCS "Casa Sollievo della Sofferenza" Hospital, San Giovanni Rotondo, Italy.
Barbara WłodarczykDepartment of Digestive Tract Diseases, Medical University of Lodz, Lodz, Poland.
Hermann BrennerDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Edita KreivenaiteDepartment of Gastroenterology, Institute for Digestive Research, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Xin GaoDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Stefania BunducInstitute for Translational Medicine, Medical School, University of Pécs, Pécs, Hungary.
Roel C H VermeulenInstitute for Risk Assessment Sciences (IRAS), Utrecht University, Utrecht, Netherlands.
Martin A SchneiderDepartment of General Surgery, University of Heidelberg, Heidelberg, Germany.
Anna LatianoDivision of Gastroenterology and Research Laboratory, Fondazione IRCCS "Casa Sollievo della Sofferenza" Hospital, San Giovanni Rotondo, Italy.
Domenica GioffredaDivision of Gastroenterology and Research Laboratory, Fondazione IRCCS "Casa Sollievo della Sofferenza" Hospital, San Giovanni Rotondo, Italy.
Sabrina G G TestoniPancreato-Biliary Endoscopy and Endosonography Division, Pancreas Translational and Clinical Research Center, IRSSC San Raffaele Scientific Institute, Milan, Italy.
Juozas KupcinskasDepartment of Gastroenterology, Institute for Digestive Research, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Rita T LawlorARC-NET, Centre for Applied Research on Cancer, University and Hospital Trust of Verona, Verona, Italy.
Gabriele CapursoDigestive and Liver Disease Unit, Sant'Andrea Hospital, Rome, Italy.
Núria MalatsGenetic and Molecular Epidemiology Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
Daniele CampaDepartment of Biology, University of Pisa, Pisa, Italy.
Federico CanzianGenomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.
University of Pisa · ITHeidelberg University · DEVita-Salute San Raffaele University · ITCasa Sollievo della Sofferenza · ITCharles University · CZLithuanian University of Health Sciences · LTUniversity of Padua · ITAzienda Usl Toscana Centro · ITGerman Cancer Research Center · DEMedical University of Lodz · PLUniversity Medical Center Hamburg-Eppendorf · DEHippocration General Hospital · GRHumanitas University · ITMeyer Children's Hospital · ITPalacký University Olomouc · CZSapienza University of Rome · ITSpanish National Cancer Research Centre · ESUniversity of Amsterdam · NLUniversity of Pecs · HUUniversity of Verona · IT
Funding
Medical Research Council MC_UU_12015/1Medical Research Council MR/N003284/1
Abstract
Genetic factors play an important role in the susceptibility to pancreatic cancer (PC). However, established loci explain a small proportion of genetic heritability for PC; therefore, more progress is needed to find the missing ones. We aimed at identifying single nucleotide polymorphisms (SNPs) affecting PC risk through effects on micro-RNA (miRNA) function. We searched
Indexed as
genetic polymorphismsmiRNApancreatic cancerpancreatic ductal adenocarcinomasusceptibility
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