Evidence map›Paper›PMID 34527002›Full record

ArticleFrontiers in immunology2021

Recognition of Multiple Hybrid Insulin Peptides by a Single Highly Diabetogenic T-Cell Receptor.

Daniel Parras, Patricia Solé, Thomas Delong, Pere Santamaría, Pau Serra

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. The immunology of type 1 diabetes.Nature reviews. Immunology · 2024
    Review
  11. De novo identification of CD4Nature methods · 2024
    Article
  12. Review
  13. Review
  14. Review
  15. Article
  16. Structural plasticity in I-AFrontiers in immunology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 3 countries.

Daniel ParrasInstitut D'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain.
Patricia SoléInstitut D'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain.
Thomas DelongSkaggs School of Pharmacy and Pharmaceutical Sciences (SSPPS), Department of Pharmaceutical Sciences, University of Colorado, Aurora, CO, United States.
Pere SantamaríaInstitut D'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain.
Pau SerraInstitut D'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain.
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer · ESUniversity of Colorado Anschutz Medical Campus · US

Funding

Characterize the Landscape and Origin of Hybrid Peptides in Beta CellsR01DK119529 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI THOMAS DELONG · 2018 to 2026
$4.8M
NIDDK NIH HHS R01 DK119529
6 · The paper itself

Abstract

The mechanisms underlying the major histocompatibility complex class II (MHCII) type 1 diabetes (T1D) association remain incompletely understood. We have previously shown that thymocytes expressing the highly diabetogenic, I-A

Indexed as

AnimalsAutoantigensCD4-Positive T-LymphocytesCHO CellsCoculture TechniquesCricetulusDiabetes Mellitus, Type 1DNA-Binding ProteinsEpitopesHEK293 CellsHistocompatibility Antigens Class IIHumansInsulinJurkat CellsMiceMice, Inbred NODAutoantigensDNA-Binding ProteinsEpitopesHistocompatibility Antigens Class IIInsulinPeptide FragmentsRag2 protein, mouseReceptors, Antigen, T-Cellantigenic promiscuityautoimmunityepitope discoverygenetic susceptibility and resistancehybrid insulin peptidesmajor histocompatibility complexTCR-transgenic NOD micetype 1 diabetes

Identifiers

PMID34527002
PMCPMC8435627
OpenAlexW3197322769

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.