ArticleFrontiers in human neuroscience2021
The Higher Parietal Cortical Thickness in Abstinent Methamphetamine Patients Is Correlated With Functional Connectivity and Age of First Usage.
Article in Frontiers in human neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Modulatory Effects of Methadone on Brain Network Instability in Methamphetamine Use; A Cross-sectional Study.Archives of academic emergency medicine · 2026Article
- Altered morphological cortical thickness and disrupted network attributes and its relationships with drug use characteristics and impulsivity in abstinent male subjects with methamphetamine use disorder.Psychological medicine · 2025Article
- Mapping structural covariance networks of emotional withdrawal symptoms in males with methamphetamine use disorder during abstinence.Addiction biology · 2024Article
- Aberrant topology of white matter networks in patients with methamphetamine dependence and its application in support vector machine-based classification.Scientific reports · 2023Article
- Brain morphometric abnormalities and their associations with affective symptoms in males with methamphetamine use disorder during abstinence.Frontiers in psychiatry · 2022Article
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Authors and funding
5 authors.
Funding
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Abstract
aimThis study aimed to explore the changes of cortical thickness in abstinent methamphetamine (MA) patients compared with healthy controls. MATERIALS AND
methodsThree-tesla structural and functional magnetic resonance imaging (MRI) was obtained from 38 abstinent methamphetamine-dependent (AMD) patients and 32 demographically equivalent healthy controls. The cortical thickness was assessed using FreeSurfer software. General linear model was used to get brain regions with significant different cortical thickness between groups (
resultsThe AMD group showed significant cortical thickness increase in one cluster located in the parietal cortex, including right posterior central gyrus, supramarginal gyrus, and superior parietal lobule. In addition, cortical thickness values of those regions were all significant and negatively correlated with the age when patients first used MA. The cortical thickness of right posterior gyrus were positively correlated with its functional connectivities with left middle frontal gyrus and both left and right medial orbitofrontal gyrus.
conclusionThe higher cortical thickness in the parietal cortex of the AMD group is in agreement with findings in related studies of increased glucose metabolism and gray matter volume. Importantly, the negative correlation between parietal cortical thickness and age of first MA suggested that adolescent brains are more vulnerable to MA's neurotoxic effect.
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