ReviewSeminars in plastic surgery2021
Bone Healing and Inflammation: Principles of Fracture and Repair.
Review in Seminars in plastic surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
91 citing papers in PubMed, 1 synthesis or guideline pooled it, 157 citations in OpenAlex.
- Fracture Fusion on Fast-Forward: Locally Administered Deferoxamine Significantly Enhances Fracture Healing in Animal Models: A Systematic Review and Meta-Analysis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Pooled it
- A cell-free lipid sterosomal therapeutic enables bone regeneration via USP18-mediated noncanonical S1P signaling.Bioactive materials · 2026Article
- Effect of hUCMSC-seeded hydroxyapatite-chitosan scaffolds on immunomodulatory cytokine expression during alveolar socket healing: an in vivo study.Odontology · 2026Article
- The Role of Endothelial Dysfunction in Fracture Healing: Mechanisms and Potential Effects on Skeletal Repair.International journal of molecular sciences · 2026Review
- Biochemical and Physicomechanical Cues of Biomaterials Guide Osteogenic Differentiation of Mesenchymal Stem Cells.International journal of molecular sciences · 2026Review
- The role and therapeutic potential of vitamins in fracture healing.Nutrition journal · 2026Review
- Efficacy and safety of fast-track surgical management for acute orthopedic fractures: a retrospective cohort analysis.BMC surgery · 2026Article
- Soft-tissue reconstruction timing in ballistic lower extremity open fractures: impact on osteomyelitis and union.Journal of orthopaedic surgery and research · 2026Article
- Injuries in deep time: interpreting competitive behaviours in extinct reptiles via palaeopathology.Biological reviews of the Cambridge Philosophical Society · 2026Review
- Bone Tissue Engineering: Scaffold Design Principles, Biomaterial Advances, and Strategies for Functional Regeneration and Clinical Translation.Bioengineering (Basel, Switzerland) · 2026Review
- Effects of Advanced Platelet-Rich Fibrin on Bone Healing in the Treatment of Canine Appendicular Fractures.Animals : an open access journal from MDPI · 2026Article
- Microenvironment engineering with injectable hydrogel-based biofunctional scaffolds for augmenting bone defect regeneration.Journal of nanobiotechnology · 2026Review
- Computational models for predicting bone fracture healing: a review of modeling approaches, predictions, and emerging strategies.Biomechanics and modeling in mechanobiology · 2026Review
- Biomaterial-assisted gene therapy for bone repair.Materials today. Bio · 2026Review
- Platelet-rich fibrin in the management of mandibular fractures.Archives of craniofacial surgery · 2026Article
- A spatiotemporal atlas of senescence-associated secretory phenotype in fracture healing: stage-dependent mechanisms and therapeutic windows.Inflammation and regeneration · 2026Review
- Clinical Applications of Biophysical Stimuli Technologies for Bone Healing.Annals of biomedical engineering · 2026Review
- Time-Course Evaluation of the In Vivo Resorption Process of Calcium Phosphates/Poly(lactide-International journal of molecular sciences · 2026Article
- Regulation of humeral fracture healing by miR-21 through SMAD7-mediated activation of Wnt/β-catenin signaling.Mammalian genome : official journal of the International Mammalian Genome Society · 2026Article
- Post-Market Clinical Follow-Up of the MAX Variable Pitch Compression Screw System in Foot and Ankle Surgery: Safety, Performance, and Patient-Reported Outcomes.Journal of clinical medicine · 2026Article
31 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bones comprise a significant percentage of human weight and have important physiologic and structural roles. Bone remodeling occurs when healthy bone is renewed to maintain bone strength and maintain calcium and phosphate homeostasis. It proceeds through four phases: (1) cell activation, (2) resorption, (3) reversal, and (4) bone formation. Bone healing, on the other hand, involves rebuilding bone following a fracture. There are two main types of bone healing, primary and secondary. Inflammation plays an integral role in both bone remodeling and healing. Therefore, a tightly regulated inflammatory response helps achieve these two processes, and levels of inflammation can have detrimental effects on bone healing. Other factors that significantly affect bone healing are inadequate blood supply, biomechanical instability, immunosuppression, and smoking. By understanding the different mechanisms of bone healing and the factors that affect them, we may have a better understanding of the underlying principles of bony fixation and thereby improve patient care.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.