ReviewSeminars in plastic surgery2021
Current Concepts in Capsular Contracture: Pathophysiology, Prevention, and Management.
Review in Seminars in plastic surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 3 syntheses or guidelines pooled it, 69 citations in OpenAlex.
- Implant Pocket Plane Selection in Primary Breast Augmentation: A Meta-Analysis and Systematic Review of Complication Profiles.Aesthetic plastic surgery · 2026Pooled it
- Breast Capsule Thickness and Clinical Capsular Contracture: A Systematic Review and Meta-Analysis.Aesthetic plastic surgery · 2026Pooled it
- Effect of Different Medications on Capsule Formation Around Miniaturized Breast Implants in Murine Models-a Systematic Review.Aesthetic plastic surgery · 2025Pooled it
- Retrospective Validation of a Tissue-Preserving Breast Augmentation Approach: From Native Tissue Geometry to Surgical Practice.Aesthetic surgery journal · 2026Article
- Systemic Tacrolimus Attenuates Peri-Implant Capsule Formation and Inflammatory/Fibrotic Signaling in a Rat Silicone Implant Model.Aesthetic plastic surgery · 2026Article
- Round Versus Anatomical Implants in Breast Reconstruction: A Systematic Review and Meta-analysis.Plastic and reconstructive surgery. Global open · 2026Article
- Reconsidering Implant Pocket Plane Selection: The Role of Implant Surface, Tissue Envelope, and Contamination Control.Aesthetic plastic surgery · 2026Article
- Shear-Wave Elastography as an Objective Diagnostic Tool for Capsular Contracture After Breast Implant Surgery: A Comparative Study.Diagnostics (Basel, Switzerland) · 2026Article
- Piezo1-A Key Pathogenic Factor in Breast Implant-Associated Capsular Contracture.Aesthetic plastic surgery · 2026Article
- Capsular Contracture in Implant-Based Breast Reconstruction: A Comprehensive Narrative Review of Pathophysiology, Risk Factors, and Contemporary Controversies.Medicina (Kaunas, Lithuania) · 2026Review
- Acellular Dermal Matrix-Associated Recurrent Capsular Contracture in a Breast Augmentation Patient.Plastic and reconstructive surgery. Global open · 2026Article
- The Effects of Ovine-Derived Reinforced Tissue Matrix Surrounding Silicone-Based Implants in a Rat Prepectoral Reconstruction Model.Bioengineering (Basel, Switzerland) · 2026Article
- Investigating the foreign body response and regenerative mechanisms in medical-grade polycaprolactone scaffold guided breast reconstruction in a porcine model.Frontiers in bioengineering and biotechnology · 2026Article
- Histopathological Analysis of Capsule Formation Around Silicone Implants Following Bacterial Contamination: An Experimental Rat Model.Aesthetic plastic surgery · 2026Article
- Understanding Capsular Contracture: Mechanisms, Management, and Patient Outcomes in Implant-based Breast Augmentation and Reconstruction.Plastic and reconstructive surgery. Global open · 2026Article
- The role of bovine pericardium matrix in immediate prepectoral breast reconstruction: Insights from the largest published retrospective series.JPRAS open · 2025Article
- Impact of Surgical Delay on Two-Stage Breast Reconstruction During the COVID-19 Pandemic: A Retrospective Analysis.Journal of clinical medicine · 2025Article
- Long-term Follow-up of Remnant Capsules After Implant Removal Without Capsulectomy: An Animal Model Study.Aesthetic surgery journal · 2025Article
- Osteopontin attenuates the foreign-body response to silicone implants.Nature biomedical engineering · 2025Article
- Safety and Performance of Postmarketing Breast Implants: An Integrated Review with Technovigilance Data.Journal of clinical medicine · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Over 400,000 women in the United States alone will have breast implant surgery each year. Although capsular contracture represents the most common complication of breast implant surgery, surgeons continue to debate the precise etiology. General agreement exists concerning the inflammatory origin of capsular fibrosis, but the inciting events triggering the inflammatory cascade appear to be multifactorial, making it difficult to predict why one patient may develop capsular contracture while another will not. Accordingly, researchers have explored many different surgical, biomaterial, and medical therapies to address these multiple factors in an attempt to prevent and treat capsular contracture. In the current paper, we aim to inform the reader on the most up-to-date understanding of the pathophysiology, prevention, and treatment of capsular contracture.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.