Evidence map›Paper›PMID 34526864›Full record

ReviewSeminars in plastic surgery2021

Negative Pressure Wound Therapy: Mechanism of Action and Clinical Applications.

Shanel Normandin, Tyler Safran, Sebastian Winocour, Carrie K Chu, Joshua Vorstenbosch, Amanda M Murphy, Peter G Davison

Registry-linked trialOpen access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Seminars in plastic surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06832787 (Prospective, Multi-Center Randomized Controlled Trial for the Combinational Use of Negative Pressure Wound Therapy), which is not on this map. Cited by 87 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
87citing papers in PubMed, 12 pooled it
16.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06832787 narecruitingnot on this mapstarted 2025, after this paper: background citation

Prospective, Multi-Center Randomized Controlled Trial for the Combinational Use of Negative Pressure Wound Therapy (NPWT) for the Treatment of Diabetic Wounds

TypeinterventionalSponsorSingapore General HospitalRan2025 to 2026Enrolled75ConditionsDiabetic Foot UlcerArmsNegative Pressure Wound Therapy, Kerecis, Delayed primary closure with local flap
3 · Its place in the literature

Who cites it

87 citing papers in PubMed, 12 syntheses or guidelines pooled it, 142 citations in OpenAlex.

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  5. Negative pressure wound therapy for the prevention of surgical site infections in orthopedic and trauma surgery: a systematic review and meta-analysis of RCTs.Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology · 2025
    Pooled it
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  7. Negative pressure wound therapy in the management of postoperative spinal wound infections: a systematic review.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2024
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27 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Shanel NormandinFaculty of Medicine, Universite de Sherbrooke, Sherbrooke, Quebec, Canada.
Tyler SafranDivision of Plastic Surgery, McGill University, Montreal, Quebec, Canada.
Sebastian WinocourDivision of Plastic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas.
Carrie K ChuDepartment of Plastic Surgery, MD Anderson Cancer Center, Houston, Texas.
Joshua VorstenboschDivision of Plastic Surgery, McGill University, Montreal, Quebec, Canada.
Amanda M MurphyDivision of Plastic Surgery, McGill University, Montreal, Quebec, Canada.
Peter G DavisonDivision of Plastic Surgery, McGill University, Montreal, Quebec, Canada.
McGill University · CABaylor College of Medicine · USThe University of Texas MD Anderson Cancer Center · USUniversité de Sherbrooke · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Negative pressure wound therapy (NPWT) promotes healing by evenly applying negative pressure on the surface of the wound. The system consists of a sponge, a semiocclusive barrier, and a fluid collection system. Its effectiveness is explained by four main mechanisms of action, including macrodeformation of the tissues, drainage of extracellular inflammatory fluids, stabilization of the environment of the wound, and microdeformation. Rarely will complications linked to NPWT occur, but special care must be taken to prevent events such as toxic shock syndrome, fistulization, bleeding, and pain. New NPWT modalities have been recently developed to make NPWT suitable for a wider variety of wounds. These include NPWT with instillation therapy (NPWTi-d), different cleansing options, and application of NPWT on primarily closed incisions. Finally, vacuum-assisted wound closure therapy has been demonstrated to be efficient for various clinical settings, such as the management of diabetic foot ulcers, pressure ulcerations, chronic wounds, and skin grafts.

Indexed as

negative pressure wound therapysemiocclusive membraneVACwounds

Identifiers

PMID34526864
PMCPMC8432996
OpenAlexW3201394398

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.