ArticleInfection and drug resistance2021
Importance of Surveillance of New Delhi Metallo-Beta-Lactamase
Article in Infection and drug resistance, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Clinical Impact of New Delhi Metallo-Beta-Lactamase-Producing Enterobacterales in Critically Ill Patients: Are We Ready to Face the Challenge?Journal of clinical medicine · 2025Article
- Genomic Epidemiology of Carbapenem-ResistantAntimicrobial agents and chemotherapy · 2023Article
- Genomics ofMicroorganisms · 2022Article
- Clinical Distribution Characteristics of 1439 Carbapenem-ResistantInfection and drug resistance · 2021Article
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Authors and funding
9 authors.
Funding
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Abstract
introductionNew Delhi metallo-β-lactamase producing
methodsWe performed a retrospective cohort study. Whole-genome sequencing (WGS) was performed on all NDM-Kpn strains; clonality and genetic relationships were further investigated.
resultsDuring the surveillance period, 17 NDM-Kpn isolates were obtained from 17 patients admitted to seven different hospitals. Eight different sequence types (STs) were detected: ST147 (n = 4), ST383 (n = 4), ST15 (n = 3), ST11 (n = 2), ST17 (n = 1), ST29 (n = 1), ST307 (n = 1) and the newly identified ST4853 (n = 1). Genetic relationships were further investigated by the WGS-based core genome MLST (cgMLST) scheme, and 5 cluster types (CTs) were identified. Whereas a substantial overall heterogeneity among isolates was detected (8 different STs were identified out of 17 isolates), the strains within each cluster showed a very high level of genome similarity. DISCUSSION: Our study highlights the key role of surveillance, which allowed taking a picture of a part of the NDM-Kpn strains circulating in Italy, adding further insight into their molecular features.
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