ArticleNature2021
UTX condensation underlies its tumour-suppressive activity.
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Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 136 papers.
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136citing papers in PubMed
12.7field-weighted citation impact, top 1% of its field
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Who cites it
136 citing papers in PubMed, 193 citations in OpenAlex.
- Biomolecular Condensates Integrate Transcriptional and Epigenetic Responses to Hypoxia.International journal of molecular sciences · 2026Review
- Chromatin condensates tune nuclear mechanosensing and preserve nuclear integrity to prevent cGAS activation.The EMBO journal · 2026Article
- From chromatin dynamics to brain disease: Polycomb-Trithorax mechanisms in neurodevelopment.Trends in neurosciences · 2026Review
- Phase separation across membranes and condensates in cell organization and function.Nature reviews. Molecular cell biology · 2026Review
- Intrinsically disordered regions restrain genomic targeting of RNA and histone demethylases in mammals and plants.Nature genetics · 2026Article
- Oxygen‑sensing histone demethylase KDM6A modulates chondrocyte‑to‑osteoblast transdifferentiation by activating the Wnt/β‑catenin pathway.International journal of molecular medicine · 2026Article
- MLL3 and MLL4 sustain hematopoietic stem cell multipotency by opposing a B-cell default state.Blood · 2026Article
- Histone methyltransferase KMT2D promotes castration-resistant prostate cancer progression by reactivating AR through FOXA1.Oncogene · 2026Article
- Exploring the functional role of XIST in breast cancer from mechanisms to clinical implications.Discover oncology · 2026Review
- The transcriptional repressor Ssn6 modulates phase separation to regulate fungal gene expression.mBio · 2026Article
- KDM6A promotes diabetic retinopathy via H3K27me3-dependent ferroptosis in Müller cells.Cell death & disease · 2026Article
- PML::RARA-negative APL-mimicking AML with a novel KMT2C::CREB3L2 fusion and RARA/RXRA-mediated sensitivity to all-trans retinoic acid.Annals of hematology · 2026Article
- Antagonistic Ubiquitin Switching by USP7 and RNF40 Orchestrates KDM6A Homeostasis to License Coronavirus Susceptibility.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Pharmacological targeting of oncogenic condensates in cancer: mechanistic insights and therapeutic opportunities.Acta pharmacologica Sinica · 2026Review
- Disrupting the Formation of YAP Condensates Promotes the Activation of AMPKα to Inhibit the Progression of Primary Liver Cancer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Unleashed condensation by recurrent mutations of an epigenetic regulator promotes cancer.bioRxiv : the preprint server for biology · 2026Article
- Liquid-Liquid Phase Separation in Major Hallmarks of Cancer.Cell proliferation · 2026Review
- Phase separation as an emerging regulatory framework in antibody class switching and genome stability.Frontiers in immunology · 2026Review
- KDM6A phosphorylation suppresses PER2 to confer a glycolytic vulnerability in HNSCC.Cell death & disease · 2025Article
- Phase-separating fusion proteins drive cancer by upsetting transcription regulation.Genome biology · 2025Article
76 more citing papers are in PubMed but not listed here.
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Authors and funding
16 authors at 3 institutions in 1 country.
Bi Shi *Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA, USA.
Wei Li *Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA, USA.ORCID http://orcid.org/0000-0003-3566-5793
Yansu Song *Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA, USA.
Zhenjia Wang *Center for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, VA, USA.
Rui JuDepartment of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA, USA.
Aleksandra UlmanDepartment of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA, USA.ORCID http://orcid.org/0000-0002-8077-6890
Jing HuDepartment of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA, USA.
Francesco PalombaLaboratory of Fluorescence Dynamics, The Henry Samueli School of Engineering, University of California, Irvine, CA, USA.ORCID http://orcid.org/0000-0002-2249-2961
Yanfang ZhaoDepartment of Biochemistry and Molecular Genetics, University of Alabama at Birmingham School of Medicine, Birmingham, AL, USA.
John Philip LeDepartment of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA, USA.
William JarrardDepartment of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA, USA.
David DimoffDepartment of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA, USA.
Michelle A DigmanLaboratory of Fluorescence Dynamics, The Henry Samueli School of Engineering, University of California, Irvine, CA, USA.ORCID http://orcid.org/0000-0003-4611-7100
Enrico GrattonLaboratory of Fluorescence Dynamics, The Henry Samueli School of Engineering, University of California, Irvine, CA, USA.
Chongzhi ZangDepartment of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA, USA.
Hao JiangDepartment of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA, USA. hj8d@virginia.edu.ORCID http://orcid.org/0000-0003-1890-9813
University of Virginia · USFluor (United States) · USUniversity of Alabama at Birmingham · US
Funding
Women's Oncology Program - WONP30CA044579 · NCI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Thomas P. Loughran · 1987 to 2026
$72.1MTRD4: Phasor analysisP41GM103540 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI GRATTON, ENRICO · 2012 to 2020
$12.5MIntegrative computational models for functional epigenomics and transcriptional regulationR35GM133712 · NIGMS · UNIVERSITY OF VIRGINIA · PI Chongzhi Zang · 2019 to 2026
$3.4MHigh-speed and high-resolution Zeiss880 multiphoton microscopy systemS10OD025156 · OD · UNIVERSITY OF VIRGINIA · PI PERIASAMY, AMMASI · 2019 to 2019
$600kZeiss 780 NLO High Sensitivity Multiphoton Microscopy SystemS10OD016446 · OD · UNIVERSITY OF VIRGINIA · PI PERIASAMY, AMMASI · 2013 to 2013
$600kDifferential biophysical properties of protein condensates formed by a tumor suppressor contribute to sexual dimorphism in cancerR21CA257936 · NCI · UNIVERSITY OF VIRGINIA · PI JIANG, HAO · 2021 to 2021
$415kNCI NIH HHS P30 CA044579NCI NIH HHS R21 CA257936NIGMS NIH HHS P41 GM103540NIGMS NIH HHS R35 GM133712NIH HHS OD016446NIH HHS S10 OD016446NIH HHS S10 OD025156
Abstract
UTX (also known as KDM6A) encodes a histone H3K27 demethylase and is an important tumour suppressor that is frequently mutated in human cancers
Indexed as
Cell DifferentiationChromatinGenes, Tumor SuppressorAnimalsDNA-Binding ProteinsEmbryonic Stem CellsHEK293 CellsHistone DemethylasesHumansIntrinsically Disordered ProteinsMiceNeoplasm ProteinsProtein Processing, Post-TranslationalTHP-1 CellsChromatinDNA-Binding ProteinsHistone DemethylasesIntrinsically Disordered ProteinsKDM6A protein, humanKMT2D protein, humanNeoplasm Proteins
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.