Evidence map›Paper›PMID 34526700›Full record

ArticleNature reviews. Gastroenterology & hepatology2021

Society for the Study of Celiac Disease position statement on gaps and opportunities in coeliac disease.

M Ines Pinto-Sanchez, Jocelyn A Silvester, Benjamin Lebwohl, Daniel A Leffler, Robert P Anderson, Amelie Therrien, Ciaran P Kelly, Elena F Verdu

Open access · bronzeAbstract readConsensus Statement
In one paragraph

Article in Nature reviews. Gastroenterology & hepatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 3 pooled it
12.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 3 syntheses or guidelines pooled it, 86 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pancreatic Cancer in Celiac Disease Patients-A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2023
    Pooled it
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Observational
  12. Celiac Disease: Beyond Diet and Food Awareness.Foods (Basel, Switzerland) · 2025
    Review
  13. Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 5 countries.

M Ines Pinto-Sanchez *Farncombe Family Digestive Health Research Institute, Hamilton, Ontario, Canada.ORCID http://orcid.org/0000-0002-9040-9824
Jocelyn A Silvester *Harvard Medical School Celiac Research Program, Boston, MA, USA.
Benjamin LebwohlCeliac Disease Center, Columbia University, New York, NY, USA.
Daniel A LefflerHarvard Medical School Celiac Research Program, Boston, MA, USA.
Robert P AndersonWesley Medical Research, The Wesley Hospital, Auchenflower, Queensland, Australia.ORCID http://orcid.org/0000-0002-0764-7267
Amelie TherrienHarvard Medical School Celiac Research Program, Boston, MA, USA.
Ciaran P KellyHarvard Medical School Celiac Research Program, Boston, MA, USA.
Elena F VerduFarncombe Family Digestive Health Research Institute, Hamilton, Ontario, Canada. verdue@mcmaster.ca.ORCID http://orcid.org/0000-0001-6346-2665
Beth Israel Deaconess Medical Center · USMcMaster University Medical Centre · CABoston Children's Hospital · USColumbia University · USWesley Hospital · AU

Funding

Mechanisms and Markers of Small Intestinal Epithelial Injury and Villous AtrophyK23DK119584 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI SILVESTER, JOCELYN ANNE · 2019 to 2023
$971k
CIHR 168840NIDDK NIH HHS K23 DK119584
6 · The paper itself

Abstract

Progress has been made in understanding coeliac disease, a relatively frequent and underappreciated immune-mediated condition that occurs in genetically predisposed individuals. However, several gaps remain in knowledge related to diagnosis and management. The gluten-free diet, currently the only available management, is not curative or universally effective (some adherent patients have ongoing duodenal injury). Unprecedented numbers of emerging therapies, including some with novel tolerogenic mechanisms, are currently being investigated in clinical trials. In March 2020, the Celiac Disease Foundation and the Society for the Study of Celiac Disease convened a consensus workshop to identify high-yield areas of research that should be prioritized. Workshop participants included leading experts in clinical practice, academia, government and pharmaceutical development, as well as representatives from patient support groups in North America. This Roadmap summarizes key advances in the field of coeliac disease and provides information on important discussions from the consensus approach to address gaps and opportunities related to the pathogenesis, diagnosis and management of coeliac disease. The morbidity of coeliac disease is often underestimated, which has led to an unmet need to improve the management of these patients. Expanded research funding is needed as coeliac disease is a potentially curable disease.

Indexed as

Biomedical ResearchCeliac DiseaseAnimalsDiet, Gluten-FreeHumansMiceResearch Support as TopicSocieties, MedicalUnited States

Identifiers

PMID34526700
PMCPMC8441249
OpenAlexW3200236850

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.