Evidence map›Paper›PMID 34526674›Full record

ReviewNature reviews. Neurology2021

Stroke in Africa: profile, progress, prospects and priorities.

Rufus O Akinyemi, Bruce Ovbiagele, Olaleye A Adeniji, Fred S Sarfo, Foad Abd-Allah, Thierry Adoukonou, Okechukwu S Ogah, Pamela Naidoo, Albertino Damasceno, Richard W Walker and 3 more

Registry-linked trialOpen access · hybridAbstract readReview
In one paragraph

Review in Nature reviews. Neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07386535 (Innovative Tools to Expand Music-Inspired Strategies for Blood Pressure and Stroke Prevention), which is not on this map. Cited by 182 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
182citing papers in PubMed, 11 pooled it
27.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07386535 naactive not recruitingnot on this mapstarted 2026, after this paper: background citation

Innovative Tools to Expand Music-Inspired Strategies for Blood Pressure and Stroke Prevention

TypeinterventionalSponsorWashington University School of MedicineRan2026 to 2027Enrolled1,412ConditionsHigh Blood Pressure, StrokeArmsMusic4Health Intervention
3 · Its place in the literature

Who cites it

182 citing papers in PubMed, 11 syntheses or guidelines pooled it, 296 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Stroke in Africa: A systematic review and meta-analysis of the incidence and case-fatality rates.International journal of stroke : official journal of the International Stroke Society · 2023
    Pooled it
  10. Pooled it
  11. Pooled it
  12. Trial
  13. Trial
  14. Trial
  15. Article
  16. Article
  17. Low-cost Rehabilitation Solutions: Lessons From LMIC Settings.Current neurology and neuroscience reports · 2026
    Review
  18. Article
  19. Article
  20. Article

122 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 8 institutions in 8 countries.

Rufus O AkinyemiNeuroscience and Ageing Research Unit, Institute for Advanced Medical Research and Training, College of Medicine, University of Ibadan, Ibadan, Nigeria. roakinyemi@com.ui.edu.ng.ORCID http://orcid.org/0000-0001-5286-428X
Bruce OvbiageleDepartment of Neurology, University College Hospital, Ibadan, Nigeria.
Olaleye A AdenijiDepartment of Medicine, Federal Medical Centre Abeokuta, Ibadan, Nigeria.ORCID http://orcid.org/0000-0002-3402-7768
Fred S SarfoKwame Nkrumah University of Science & Technology, Kumasi, Ghana.
Foad Abd-AllahDepartment of Neurology, Kasr Alainy School of Medicine, Cairo University, Cairo, Egypt.
Thierry AdoukonouDepartment of Neurology, University Teaching Hospital, Parakou, Benin.
Okechukwu S OgahNeuroscience and Ageing Research Unit, Institute for Advanced Medical Research and Training, College of Medicine, University of Ibadan, Ibadan, Nigeria.
Pamela NaidooHeart and Stroke Foundation South Africa/University of the Western Cape, Cape Town, South Africa.
Albertino DamascenoDepartment of Cardiology, Faculty of Medicine, Eduardo Mondlane University, Maputo, Mozambique.
Richard W WalkerNeuroscience and Ageing Research Unit, Institute for Advanced Medical Research and Training, College of Medicine, University of Ibadan, Ibadan, Nigeria.
Adesola OgunniyiNeuroscience and Ageing Research Unit, Institute for Advanced Medical Research and Training, College of Medicine, University of Ibadan, Ibadan, Nigeria.
Rajesh N Kalaria *Neuroscience and Ageing Research Unit, Institute for Advanced Medical Research and Training, College of Medicine, University of Ibadan, Ibadan, Nigeria.ORCID http://orcid.org/0000-0001-7907-4923
Mayowa O Owolabi *Neuroscience and Ageing Research Unit, Institute for Advanced Medical Research and Training, College of Medicine, University of Ibadan, Ibadan, Nigeria.
University of Ibadan · NGCairo University · EGEduardo Mondlane University · MZFederal Medical Centre · NGKomfo Anokye Teaching Hospital · GHSouth African Heart Association · ZAUniversité de Parakou · BJUniversity of California, San Francisco · US

Funding

Stroke Investigative Research & Educational Network (SIREN)U54HG007479 · NHGRI · COLLEGE OF MEDICINE, UNIVERSITY OF IBADAN · PI OVBIAGELE, BRUCE, OWOLABI, MAYOWA OJO · 2013 to 2017
$4.2M
Systematic Investigation of Blacks with Stroke - Genomics (SIBS-Genomics) StudyR01NS107900 · NINDS · COLLEGE OF MEDICINE, UNIVERSITY OF IBADAN · PI OVBIAGELE, BRUCE, OWOLABI, MAYOWA OJO · 2018 to 2021
$1.8M
African Neurobiobank for Precision Stroke Medicine - (ELSI) ProjectU01HG010273 · NHGRI · COLLEGE OF MEDICINE, UNIVERSITY OF IBADAN · PI AKINYEMI, RUFUS OLUSOLA, ARULOGUN, OYEDUNNI SOLA · 2018 to 2022
$512k
NHGRI NIH HHS U01 HG010273NHGRI NIH HHS U54 HG007479NINDS NIH HHS R01 NS107900
6 · The paper itself

Abstract

Stroke is a leading cause of disability, dementia and death worldwide. Approximately 70% of deaths from stroke and 87% of stroke-related disability occur in low-income and middle-income countries. At the turn of the century, the most common diseases in Africa were communicable diseases, whereas non-communicable diseases, including stroke, were considered rare, particularly in sub-Saharan Africa. However, evidence indicates that, today, Africa could have up to 2-3-fold greater rates of stroke incidence and higher stroke prevalence than western Europe and the USA. In Africa, data published within the past decade show that stroke has an annual incidence rate of up to 316 per 100,000, a prevalence of up to 1,460 per 100,000 and a 3-year fatality rate greater than 80%. Moreover, many Africans have a stroke within the fourth to sixth decades of life, with serious implications for the individual, their family and society. This age profile is particularly important as strokes in younger people tend to result in a greater loss of self-worth and socioeconomic productivity than in older individuals. Emerging insights from research into stroke epidemiology, genetics, prevention, care and outcomes offer great prospects for tackling the growing burden of stroke on the continent. In this article, we review the unique profile of stroke in Africa and summarize current knowledge on stroke epidemiology, genetics, prevention, acute care, rehabilitation, outcomes, cost of care and awareness. We also discuss knowledge gaps, emerging priorities and future directions of stroke medicine for the more than 1 billion people who live in Africa.

Indexed as

AfricaAfrica South of the SaharaAge FactorsCause of DeathHumansIncidenceStrokeStroke Rehabilitation

Identifiers

PMID34526674
PMCPMC8441961
OpenAlexW3200505596

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.