ArticleCommunications biology2021
Connectivity alterations in autism reflect functional idiosyncrasy.
Article in Communications biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
50 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.
- Naturalistic stimuli in neuroimaging studies of autism spectrum disorder: a systematic review.Frontiers in human neuroscience · 2026Pooled it
- Brain morphology network profiles in male and female youth with autism.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Dynamic Functional Synchronization Profiles in Autism Differ by Spatial Scale and Along Hierarchical Cortical Gradients.Biological psychiatry global open science · 2026Article
- Functional Brain Asymmetry Reveals Heterogeneous Subtypes in Autism Spectrum Disorder.Autism research : official journal of the International Society for Autism Research · 2026Article
- Feature overlap in transdiagnostic connectome-based models of sustained attention and autism symptoms.medRxiv : the preprint server for health sciences · 2026Article
- Functional brain growth trajectories across the first decade of life from a single longitudinal cohort.Research square · 2026Article
- Brain idiosyncrasy during biological-motion perception is amplified in autistic individuals with intellectual impairment.Journal of neurodevelopmental disorders · 2026Article
- Node persistence from topological data analysis reveals changes in brain functional connectivity.Patterns (New York, N.Y.) · 2026Article
- Detection of Idiosyncratic Gaze-Fingerprint Signatures in Humans.Psychological science · 2026Article
- Autism Spectrum Disorder in the Genomic Era: A Comprehensive Review of Etiology, Precision Diagnostics, Clinical Outcomes, and Emerging Gene-Editing Therapies.Neuropsychiatric disease and treatment · 2026Review
- A Multimodal Framework for Understanding Perceptual Segmentation of Natural Scenes In Autism.bioRxiv : the preprint server for biology · 2025Article
- Subtyping Autism Spectrum Disorder With a Population Graph-Based Dual Autoencoder: Revealing Two Distinct Biotypes.CNS neuroscience & therapeutics · 2025Article
- Asymmetric developmental bifurcations in polarized environments: a new class of human variants, which may include autism.Molecular psychiatry · 2025Review
- Lateral Cerebellar Theta Burst Stimulation Can Modulate Default Mode Network Connectivity in Autistic Adults.Cerebellum (London, England) · 2025Article
- Behavioral and neural interrelationships of sensory difficulties, intolerance of uncertainty, and anxiety in autistic children.Research in autism · 2025Article
- A cross-cultural examination of bi-directional mentalising in autistic and non-autistic adults.Molecular autism · 2025Article
- Generalizable and transportable resting-state neural signatures characterized by functional networks, neurotransmitters, and clinical symptoms in autism.Molecular psychiatry · 2025Article
- Altered Patterns of Dynamic Functional Connectivity Underpin Reduced Expressions of Social-Emotional Reciprocity in Autistic Adults.Autism research : official journal of the International Society for Autism Research · 2025Article
- Atypical maturation of the functional connectome hierarchy in autism.Molecular autism · 2025Article
- Dynamic functional adaptations during touch observation in autism: connectivity strength is linked to attitudes towards social touch and social responsiveness.Molecular autism · 2025Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 4 countries.
Funding
Abstract
Autism spectrum disorder (ASD) is commonly understood as an alteration of brain networks, yet case-control analyses against typically-developing controls (TD) have yielded inconsistent results. Here, we devised a novel approach to profile the inter-individual variability in functional network organization and tested whether such idiosyncrasy contributes to connectivity alterations in ASD. Studying a multi-centric dataset with 157 ASD and 172 TD, we obtained robust evidence for increased idiosyncrasy in ASD relative to TD in default mode, somatomotor and attention networks, but also reduced idiosyncrasy in lateral temporal cortices. Idiosyncrasy increased with age and significantly correlated with symptom severity in ASD. Furthermore, while patterns of functional idiosyncrasy were not correlated with ASD-related cortical thickness alterations, they co-localized with the expression patterns of ASD risk genes. Notably, we could demonstrate that patterns of atypical idiosyncrasy in ASD closely overlapped with connectivity alterations that are measurable with conventional case-control designs and may, thus, be a principal driver of inconsistency in the autism connectomics literature. These findings support important interactions between inter-individual heterogeneity in autism and functional signatures. Our findings provide novel biomarkers to study atypical brain development and may consolidate prior research findings on the variable nature of connectome level anomalies in autism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.