ArticleScientific reports2021
Acute regional changes in myocardial strain may predict ventricular remodelling after myocardial infarction in a large animal model.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 11 citations in OpenAlex.
- MiR-132 inhibition improves myocardial strain in a large animal model of chronic left ventricular adverse remodelling.European heart journal. Imaging methods and practice · 2025Article
- Correlation of Noninvasive Cardiac MRI Measures of Left Ventricular Myocardial Function and Invasive Pressure-Volume Parameters in a Porcine Ischemia-Reperfusion Model.Radiology. Cardiothoracic imaging · 2024Article
- Intramyocardial immunomodulation with human CD16Frontiers in cardiovascular medicine · 2024Article
- Improved methodology for efficient establishment of the myocardial ischemia-reperfusion model in pigs through the median thoracic incision.Journal of biomedical research · 2023Article
- From multi-omics approaches to personalized medicine in myocardial infarction.Frontiers in cardiovascular medicine · 2023Review
- MRI-based strain measurements reflect morphological changes following myocardial infarction: A study on the UK Biobank cohort.Journal of anatomy · 2023Article
- Ultra-high field cardiac MRI in large animals and humans for translational cardiovascular research.Frontiers in cardiovascular medicine · 2023Article
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Authors and funding
15 authors at 6 institutions in 1 country.
Funding
Abstract
To identify predictors of left ventricular remodelling (LVR) post-myocardial infarction (MI) and related molecular signatures, a porcine model of closed-chest balloon MI was used along with serial cardiac magnetic resonance imaging (CMRI) up to 5-6 weeks post-MI. Changes in myocardial strain and strain rates were derived from CMRI data. Tissue proteomics was compared between infarcted and non-infarcted territories. Peak values of left ventricular (LV) apical circumferential strain (ACS) changed over time together with peak global circumferential strain (GCS) while peak GLS epicardial strains or strain rates did not change over time. Early LVR post-MI enhanced abundance of 39 proteins in infarcted LV territories, 21 of which correlated with LV equatorial circumferential strain rate. The strongest associations were observed for D-3-phosphoglycerate dehydrogenase (D-3PGDH), cysteine and glycine-rich protein-2, and secreted frizzled-related protein 1 (sFRP1). This study shows that early changes in regional peak ACS persist at 5-6 weeks post-MI, when early LVR is observed along with increased tissue levels of D-3PGDH and sFRP1. More studies are needed to ascertain if the observed increase in tissue levels of D-3PGDH and sFRP1 might be casually involved in the pathogenesis of adverse LV remodelling.
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