ArticleScientific reports2021
Semiautomated 3D mapping of aneurysmal wall enhancement with 7T-MRI.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The trial behind it
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Who cites it
22 citing papers in PubMed, 30 citations in OpenAlex.
- Analysis of symptomatic brain aneurysms with three-dimensional aneurysm wall enhancement.Neurosurgical review · 2026Observational
- Voxel-Wise Quantification and Multi-planar Visualization of Plaque Contrast Enhancement in Intracranial Vessel Wall MRI.medRxiv : the preprint server for health sciences · 2025Article
- Inter-rater reliability of atherosclerotic plaque enhancement on 7 T vessel wall MRI: Comparison with quantitative analysis.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025Article
- Imaging of Intracranial Aneurysms: A Review of Standard and Advanced Imaging Techniques.Translational stroke research · 2025Review
- Hemodynamic analysis of thrombosed intracranial aneurysms: a comparative correlation study.Neurosurgical review · 2025Article
- The effect of aspirin on aneurysm wall enhancement: A study in rabbits and humans.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025Article
- Beyond Size: Advanced MRI Breakthroughs in Predicting Intracranial Aneurysm Rupture Risk.Journal of clinical medicine · 2025Review
- There Is Poor Agreement between the Subjective and Quantitative Adjudication of Aneurysm Wall Enhancement.AJNR. American journal of neuroradiology · 2025Article
- Radiomics-Based Predictive Nomogram for Assessing the Risk of Intracranial Aneurysms.Translational stroke research · 2025Article
- Statins may Decrease Aneurysm wall Enhancement of Unruptured Fusiform Intracranial Aneurysms: A high-resolution 3T MRI Study.Translational stroke research · 2024Article
- Radiomics-Based Predictive Nomogram for Assessing the Risk of Intracranial Aneurysms.Research square · 2024Article
- Clinical Scales in Aneurysm Rupture Prediction.Stroke (Hoboken, N.J.) · 2024Review
- Intracranial Atherosclerotic Plaque Morphologic Pattern and Enhancement Change With High-Intensity Statin Therapy.Stroke (Hoboken, N.J.) · 2023Article
- Imaging of Intracranial Saccular Aneurysms.Stroke (Hoboken, N.J.) · 2023Review
- Radiomics Features in Contrast-Enhanced and Nonenhanced Magnetic Resonance Imaging Images Are Associated With High Intracranial Aneurysmal Risk.Stroke (Hoboken, N.J.) · 2023Article
- 3D aneurysm wall enhancement is associated with symptomatic presentation.Journal of neurointerventional surgery · 2023Article
- Three-dimensional aneurysm wall enhancement in fusiform intracranial aneurysms is associated with aneurysmal symptoms.Frontiers in neuroscience · 2023Article
- Brain Aneurysm Biology: What Can We Learn From Imaging?Stroke (Hoboken, N.J.) · 2022Article
- Topographical Analysis of Aneurysm Wall Enhancement With 3-Dimensional Mapping.Stroke (Hoboken, N.J.) · 2022Article
- Aneurysmal wall enhancement and hemodynamics: pixel-level correlation between spatial distribution.Quantitative imaging in medicine and surgery · 2022Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
Aneurysm wall enhancement (AWE) after the administration of contrast gadolinium is a potential biomarker of unstable intracranial aneurysms. While most studies determine AWE subjectively, this study comprehensively quantified AWE in 3D imaging using a semi-automated method. Thirty patients with 33 unruptured intracranial aneurysms prospectively underwent high-resolution imaging with 7T-MRI. The signal intensity (SI) of the aneurysm wall was mapped and normalized to the pituitary stalk (PS) and corpus callosum (CC). The CC proved to be a more reliable normalizing structure in detecting contrast enhancement (p < 0.0001). 3D-heatmaps and histogram analysis of AWE were used to generate the following metrics: specific aneurysm wall enhancement (SAWE), general aneurysm wall enhancement (GAWE) and focal aneurysm wall enhancement (FAWE). GAWE was more accurate in detecting known morphological determinants of aneurysm instability such as size ≥ 7 mm (p = 0.049), size ratio (p = 0.01) and aspect ratio (p = 0.002). SAWE and FAWE were aneurysm specific metrics used to characterize enhancement patterns within the aneurysm wall and the distribution of enhancement along the aneurysm. Blebs were easily identified on 3D-heatmaps and were more enhancing than aneurysm sacs (p = 0.0017). 3D-AWE mapping may be a powerful objective tool in characterizing different biological processes of the aneurysm wall.
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Registered trials
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