ArticleScientific reports2021
Rheotaxis-based sperm separation using a biomimicry microfluidic device.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- A sperm racetrack to separate sperm by swim speed.Lab on a chip · 2026Article
- Recent advances in sex-specific reproductive microphysiological systems for the systematic evaluation of assisted reproductive technology.Materials today. Bio · 2026Review
- Separation of sperm based on rheotaxis mechanism using a microfluidic device.Clinical and experimental reproductive medicine · 2026Article
- DNA forensics at forty: the way forward.International journal of legal medicine · 2025Review
- Sperm DNA Fragmentation Impairs Early Embryo Development but Is Not Predictive of Pregnancy Outcomes: Insights from 870 ICSI Cycles.International journal of molecular sciences · 2025Article
- Integration of Bioengineered Tools in Assisted Reproductive Technologies.Advanced healthcare materials · 2025Review
- Simple and rapid microfluidic device for processing raw human semen and separation of motile sperm based on their intrinsic behavior and morphology.Scientific reports · 2025Article
- Microfluidic Sorting Can Be Applied for Assisted Reproduction Sperm Selection in Different Cases of Semen Abnormalities.Life (Basel, Switzerland) · 2025Article
- Advancements in differentiation between sperm cells and epithelial cells for efficient forensic DNA analysis in sexual assault cases.International journal of legal medicine · 2024Review
- Impact of various cryo-preservation steps on sperm rheotaxis and sperm kinematics in bull.Scientific reports · 2024Article
- Qualified sperm selection based on the rheotaxis and thigmotaxis in a microfluidic system.Biomedical engineering letters · 2023Article
- Design of a gradient-rheotaxis microfluidic chip for sorting of high-quality Sperm with progressive motility.iScience · 2023Article
- Enhancing the Accuracy of Measuring DEP Force Applied on Cells by Considering the Friction Effect.Biosensors · 2023Article
- Sperm selection by the oviduct: perspectives for male fertility and assisted reproductive technologies†.Biology of reproduction · 2023Article
- A novel microfluidic device with parallel channels for sperm separation using spermatozoa intrinsic behaviors.Scientific reports · 2023Article
- Lab-on-chip (LoC) application for quality sperm selection: An undelivered promise?Open research Europe · 2023Review
- Disposable paper-based microfluidics for fertility testing.iScience · 2022Review
- Separation of motile human sperms in a T-shaped sealed microchannel.Biomedical engineering letters · 2022Article
- Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sperm selection is crucial to assisted reproduction, influencing the success rate of the treatment cycle and offspring health. However, in the current clinical sperm selection practices, bypassing almost all the natural selection barriers is a major concern. Here, we present a biomimicry microfluidic method, inspired by the anatomy of the female reproductive tract, that separates motile sperm based on their rheotaxis behavior to swim against the flow into low shear rate regions. The device includes micropocket geometries that recall the oval-shaped microstructures of the female fallopian tube to create shear protected zones for sperm separation. Clinical tests with human samples indicate that the device is capable of isolating viable and highly motile sperm based on their rheotaxis responses, resulting in a separation efficiency of 100%. The device presents an automated alternative for the current sperm selection practices in assisted reproduction.
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Registered trials
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