Evidence map›Paper›PMID 34526525›Full record

ArticleScientific reports2021

K

Felix Glaser, Petra Hundehege, Etmar Bulk, Luca Matteo Todesca, Sandra Schimmelpfennig, Elke Nass, Thomas Budde, Sven G Meuth, Albrecht Schwab

Abstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Targeting KCell death discovery · 2024
    Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Imaging of KChemMedChem · 2023
    Article
  13. Review
  14. Functional expression of mitochondrial KPflugers Archiv : European journal of physiology · 2022
    Article
  15. IKCell death & disease · 2022
    Article
  16. Article
  17. Review
  18. Review
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Felix GlaserInstitut für Physiologie II, Westfälische Wilhelms-Universität, Robert-Koch-Str. 27b, 48149, Münster, Germany.
Petra HundehegeDepartment of Neurology with Institute of Translational Neurology, Westfälische Wilhelms-Universität, Münster, Germany.
Etmar BulkInstitut für Physiologie II, Westfälische Wilhelms-Universität, Robert-Koch-Str. 27b, 48149, Münster, Germany.
Luca Matteo TodescaInstitut für Physiologie II, Westfälische Wilhelms-Universität, Robert-Koch-Str. 27b, 48149, Münster, Germany.
Sandra SchimmelpfennigInstitut für Physiologie II, Westfälische Wilhelms-Universität, Robert-Koch-Str. 27b, 48149, Münster, Germany.
Elke NassInstitut für Physiologie I, Westfälische Wilhelms-Universität, Münster, Germany.
Thomas BuddeInstitut für Physiologie I, Westfälische Wilhelms-Universität, Münster, Germany.
Sven G MeuthDepartment of Neurology with Institute of Translational Neurology, Westfälische Wilhelms-Universität, Münster, Germany.
Albrecht SchwabInstitut für Physiologie II, Westfälische Wilhelms-Universität, Robert-Koch-Str. 27b, 48149, Münster, Germany. aschwab@uni-muenster.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non-small cell lung cancer (NSCLC) has a poor prognosis with a 5 year survival rate of only ~ 10%. Important driver mutations underlying NSCLC affect the epidermal growth factor receptor (EGFR) causing the constitutive activation of its tyrosine kinase domain. There are efficient EGFR tyrosine kinase inhibitors (TKIs), but patients develop inevitably a resistance against these drugs. On the other hand, K

Indexed as

A549 CellsCarcinoma, Non-Small-Cell LungCell Line, TumorCell MovementCell ProliferationDrug Resistance, NeoplasmDrug SynergismErbB ReceptorsErlotinib HydrochlorideGene Expression ProfilingHumansLarge-Conductance Calcium-Activated Potassium ChannelsLung NeoplasmsPotassium Channel BlockersProtein Kinase InhibitorsSingle-Cell AnalysisEGFR protein, humanErbB ReceptorsErlotinib HydrochlorideLarge-Conductance Calcium-Activated Potassium ChannelsPotassium Channel BlockersProtein Kinase Inhibitors

Identifiers

PMID34526525
PMCPMC8443639

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.