Evidence map›Paper›PMID 34526390›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2021

Loss of Christianson Syndrome Na

Matthew F Pescosolido, Qing Ouyang, Judy S Liu, Eric M Morrow

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
7.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 53 citations in OpenAlex.

  1. Article
  2. Article
  3. The Recycling Endosomal (NaActa physiologica (Oxford, England) · 2026
    Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Autophagic stress activates distinct compensatory secretory pathways in neurons.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  11. Alterations in the NaCerebellum (London, England) · 2025
    Article
  12. Article
  13. Neurology. Genetics · 2025
    Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. The ion channels of endomembranes.Physiological reviews · 2024
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Matthew F PescosolidoDepartment of Molecular Biology, Cell Biology and Biochemistry, Laboratories for Molecular Medicine, Brown University, 70 Ship Street, Providence, RI 02912.
Qing OuyangDepartment of Molecular Biology, Cell Biology and Biochemistry, Laboratories for Molecular Medicine, Brown University, 70 Ship Street, Providence, RI 02912.
Judy S LiuDepartment of Molecular Biology, Cell Biology and Biochemistry, Laboratories for Molecular Medicine, Brown University, 70 Ship Street, Providence, RI 02912.
Eric M MorrowDepartment of Molecular Biology, Cell Biology and Biochemistry, Laboratories for Molecular Medicine, Brown University, 70 Ship Street, Providence, RI 02912 eric_morrow@brown.edu.ORCID 0000-0003-3430-3520
Allen Institute for Brain Science · US

Funding

Pathogenic Mechanisms in Christianson Syndrome and NHE6-Related DisordersR01NS113141 · NINDS · BROWN UNIVERSITY · PI Eric M Morrow · 2019 to 2026
$7.0M
Mechanisms of circuit failure and treatments in patient-derived neurons in autismR01MH105442 · NIMH · BROWN UNIVERSITY · PI MORROW, ERIC M · 2014 to 2019
$2.8M
Neuroscience Advanced Predoctoral Institutional Training GrantT32NS062443 · NINDS · BROWN UNIVERSITY · PI LIPSCOMBE, DIANE, MOORE, CHRISTOPHER I · 2008 to 2018
$1.8M
Autism-linked endosomal mechanisms in neuronal arborization and connectivityR01MH102418 · NIMH · BROWN UNIVERSITY · PI MORROW, ERIC M · 2015 to 2018
$1.6M
Convergent Cellular Mechanisms Governed by UBE3A and NHEs in NeuronsR21MH115392 · NIMH · BROWN UNIVERSITY · PI MORROW, ERIC M · 2017 to 2018
$447k
Endo-lysosomal mechanisms and treatment in atypical cerebellar neurodevelopmentF31NS093880 · NINDS · BROWN UNIVERSITY · PI PESCOSOLIDO, MATTHEW F. · 2016 to 2017
$88k
NIMH NIH HHS R01 MH102418NIMH NIH HHS R01 MH105442NIMH NIH HHS R21 MH115392NINDS NIH HHS F31 NS093880NINDS NIH HHS R01 NS113141NINDS NIH HHS T32 NS062443
6 · The paper itself

Abstract

Loss-of-function mutations in endosomal Na

Indexed as

Loss of Function MutationAnimalsAtaxiaCathepsin DCells, CulturedEndosomesEpilepsyGenetic Diseases, X-LinkedHippocampusIntellectual DisabilityLysosomesMiceMicrocephalyNeuronsOcular Motility DisordersProtein TransportCathepsin DNHE6 protein, mouseSodium-Hydrogen ExchangersChristianson syndromeendosomeexosomelysosomeneurodegenerationNHE6

Identifiers

PMID34526390
PMCPMC8570832
OpenAlexW3201400965

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.