Evidence map›Paper›PMID 34526345›Full record

ArticleBMJ open2021

Searching for a technology-driven acute rheumatic fever test: the START study protocol.

Anna P Ralph, Rachel Webb, Nicole J Moreland, Reuben McGregor, Anthony Bosco, David Broadhurst, Timo Lassmann, Timothy C Barnett, Rym Benothman, Jennifer Yan and 7 more

Open access · goldAbstract read
In one paragraph

Article in BMJ open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Acute rheumatic fever and rheumatic heart disease.Nature reviews. Disease primers · 2026
    Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Streptococcal Serology Reference Intervals in an Australian Pediatric Cohort.Journal of the Pediatric Infectious Diseases Society · 2025
    Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. Evaluation of an ARF diagnosis calculator: a survey and content analysis.BMC medical informatics and decision making · 2022
    Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 6 institutions in 2 countries.

Anna P RalphGlobal and Tropical Health, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia anna.ralph@menzies.edu.au.ORCID 0000-0002-2253-5749
Rachel WebbKidzFirst Hospital, Counties Manukau District Health Board, Auckland, New Zealand.
Nicole J MorelandSchool of Medical Sciences and Maurice Wilkins Centre, The University of Auckland, Auckland, New Zealand.
Reuben McGregorSchool of Medical Sciences and Maurice Wilkins Centre, The University of Auckland, Auckland, New Zealand.
Anthony BoscoWesfarmers Centre for Vaccines and Infectious Diseases, Telethon Kids Institute, Perth, Western Australia, Australia.
David BroadhurstCentre for Integrative Metabolomics and Computational Biology, Edith Cowan University, Perth, Western Australia, Australia.
Timo LassmannWesfarmers Centre for Vaccines and Infectious Diseases, Telethon Kids Institute, Perth, Western Australia, Australia.
Timothy C BarnettWesfarmers Centre for Vaccines and Infectious Diseases, Telethon Kids Institute, Perth, Western Australia, Australia.
Rym BenothmanWesfarmers Centre for Vaccines and Infectious Diseases, Telethon Kids Institute, Perth, Western Australia, Australia.
Jennifer YanGlobal and Tropical Health, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.
Bo RemenyiGlobal and Tropical Health, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.
Julie BennettDepartment of Public Health, University of Otago, Wellington, New Zealand.
Nigel WilsonStarship Children's Hospital, Auckland, New Zealand.
Mark MayoGlobal and Tropical Health, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.
Glenn PearsonWesfarmers Centre for Vaccines and Infectious Diseases, Telethon Kids Institute, Perth, Western Australia, Australia.
Tobias KollmannWesfarmers Centre for Vaccines and Infectious Diseases, Telethon Kids Institute, Perth, Western Australia, Australia.
Jonathan R CarapetisWesfarmers Centre for Vaccines and Infectious Diseases, Telethon Kids Institute, Perth, Western Australia, Australia.
The Kids Research Institute Australia · AUCharles Darwin University · AUUniversity of Auckland · NZEdith Cowan University · AUStarship Children's Health · NZUniversity of Otago · NZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe absence of a diagnostic test for acute rheumatic fever (ARF) is a major impediment in managing this serious childhood condition. ARF is an autoimmune condition triggered by infection with group A ETHICS AND DISSEMINATION: The study has approval from the Northern Territory Department of Health and Menzies School of Health Research ethics committee and the New Zealand Health and Disability Ethics Committee. It will be conducted according to ethical standards for research involving Indigenous Australians and New Zealand Māori and Pacific Peoples. Indigenous investigators and governance groups will provide oversight of study processes and advise on cultural matters.

Indexed as

Rheumatic FeverRheumatic Heart DiseaseChildCohort StudiesHumansNorthern TerritoryTechnologydiagnostic microbiologyimmunologypaediatric rheumatologyvalvular heart disease

Identifiers

PMID34526345
PMCPMC8444258
OpenAlexW3199282533

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.