ArticleBMJ open2021
Falls: a marker of preclinical Alzheimer disease: a cohort study protocol.
Article in BMJ open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04949529 (Falls), which is not on this map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Falls: A Marker of Preclinical Alzheimer Disease
Who cites it
14 citing papers in PubMed, 18 citations in OpenAlex.
- Falls predict faster progression to Alzheimer's dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Association between falls and dementia risk: Evidence from three cohort studies.Journal of translational internal medicine · 2025Article
- Review
- Exploring the Remote Administration of a Performance-Based Functional Assessment.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2025Article
- Falls prevention in an older adult mental health ward through a quality improvement initiative.BMJ open quality · 2024Article
- The Association Between Postural Sway and Preclinical Alzheimer Disease Among Community-Dwelling Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Examining the impact of a health report card on follow through with fall risk recommendations: an observational study.BMC geriatrics · 2024Observational
- Gut microbiome composition may be an indicator of preclinical Alzheimer's disease.Science translational medicine · 2023Article
- Precipitating Mechanisms of Falls in Preclinical Alzheimer's Disease.Journal of Alzheimer's disease reports · 2023Article
- Injurious falls before, during and after dementia diagnosis: a population-based study.Age and ageing · 2022Article
- Assessment of Instrumental Activities of Daily Living in Preclinical Alzheimer Disease.OTJR : occupation, participation and health · 2022Article
- Higher amyloid is associated with greater loneliness among cognitively normal older adults during the COVID-19 pandemic.F1000Research · 2022Article
- Article
- Down syndrome and Alzheimer's disease: A scoping review of functional performance and fall risk.Alzheimer's & dementia (New York, N. Y.)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 1 institution in 1 country.
Funding
Abstract
introductionProgression to symptomatic Alzheimer disease (AD) occurs slowly over a series of preclinical stages. Declining functional mobility may be an early indicator of loss of brain network integration and may lead to an increased risk of experiencing falls. It is unknown whether measures of functional mobility and falls are preclinical markers of AD. The purpose of this study is to examine (1) the relationship between falls and functional mobility with AD biomarkers to determine when falls occur within the temporal progression to symptomatic Alzheimer disease, and (2) the attentional compared with perceptual/motor systems that underlie falls and functional mobility changes seen with AD. METHODS AND ANALYSIS: This longitudinal cohort study will be conducted at the Knight Alzheimer Disease Research Center. Approximately 350 cognitively normal participants (with and without preclinical AD) will complete an in-home visit every year for 4 years. During each yearly assessment, functional mobility will be assessed using the Performance Oriented Mobility Assessment, Timed Up and Go, and Timed Up and Go dual task. Data regarding falls (including number and severity) will be collected monthly by self-report and confirmed through interviews. This study will leverage ongoing neuropsychological assessments and neuroimaging (including molecular imaging using positron emission tomography and MRI) performed by the Knight Alzheimer Disease Research Center. Relationships between falls and biomarkers of amyloid, tau and neurodegeneration will be evaluated. ETHICS AND DISSEMINATION: This study was approved by the Washington University in St. Louis Institutional Review Board (reference number 201807135). Written informed consent will be obtained in the home prior to the collection of any study data. Results will be published in peer-reviewed publications and presented at national and international conferences. TRIAL REGISTRATION NUMBER: NCT04949529; Pre-results.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.