ArticleParasites & vectors2021
Contrasting effects of the alkaloid ricinine on the capacity of Anopheles gambiae and Anopheles coluzzii to transmit Plasmodium falciparum.
Article in Parasites & vectors, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 32 citations in OpenAlex.
- Effects of a bloodless diet on fitness and malaria susceptibility in Anopheles mosquitoes from Burkina Faso.Scientific reports · 2026Article
- Effects of a caffeine-based diet on insecticide resistance and longevity in infected Anopheles coluzzii.Parasites & vectors · 2026Article
- Identifying mosquito plant hosts from ingested nectar secondary metabolites.Scientific reports · 2025Article
- A simple, field-applicable method to increase the infectivity of wild isolates of Plasmodium falciparum to mosquito vectors.Malaria journal · 2024Article
- The paradox of plant preference: The malaria vectorsEcology and evolution · 2024Article
- Intervention reducing malaria parasite load in vector mosquitoes: No impact on Plasmodium falciparum extrinsic incubation period and the survival of Anopheles gambiae.PLoS pathogens · 2023Article
- Contemporary exploitation of natural products for arthropod-borne pathogen transmission-blocking interventions.Parasites & vectors · 2022Review
- Using an antimalarial in mosquitoes overcomes Anopheles and Plasmodium resistance to malaria control strategies.PLoS pathogens · 2022Article
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Authors and funding
15 authors at 7 institutions in 4 countries.
Funding
Abstract
backgroundBesides feeding on blood, females of the malaria vector Anopheles gambiae sensu lato readily feed on natural sources of plant sugars. The impact of toxic secondary phytochemicals contained in plant-derived sugars on mosquito physiology and the development of Plasmodium parasites remains elusive. The focus of this study was to explore the influence of the alkaloid ricinine, found in the nectar of the castor bean Ricinus communis, on the ability of mosquitoes to transmit Plasmodium falciparum.
methodsFemales of Anopheles gambiae and its sibling species Anopheles coluzzii were exposed to ricinine through sugar feeding assays to assess the effect of this phytochemical on mosquito survival, level of P. falciparum infection and growth rate of the parasite.
resultsRicinine induced a significant reduction in the longevity of both Anopheles species. Ricinine caused acceleration in the parasite growth rate with an earlier invasion of the salivary glands in both species. At a concentration of 0.04 g l
conclusionsOverall, our findings reveal that consumption of certain nectar phytochemicals can have unexpected and contrasting effects on key phenotypic traits that govern the intensity of malaria transmission. Further studies will be required before concluding on the putative role of ricinine as a novel control agent, including the development of ricinine-based toxic and transmission-blocking sugar baits. Testing other secondary phytochemicals in plant nectar will provide a broader understanding of the impact which plants can have on the transmission of vector-borne diseases.
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