ArticleBiomedical engineering online2021
Beam orientation optimization for coherent X-ray scattering from distributed deep targets.
Article in Biomedical engineering online, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundAmyloid deposits in the temporal and frontal lobes in patients with Alzheimer's disease make them potential targets to aid in early diagnosis. Recently, spectral small-angle X-ray scattering techniques have been proposed for interrogating deep targets such as amyloid plaques.
resultsWe describe an optimization approach for the orientation of beams for deep target characterization. The model predicts the main features of scattering profiles from targets with varying shape, size and location. We found that increasing target size introduced additional smearing due to location uncertainty, and incidence angle affected the scattering profile by altering the path length or effective target size. For temporal and frontal lobe targets, beam effectiveness varied up to 2 orders of magnitude.
conclusionsBeam orientation optimization might allow for patient-specific optimal paths for improved signal characterization.
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