ArticleBMC public health2021
Comparisons of disease cluster patterns, prevalence and health factors in the USA, Canada, England and Ireland.
Article in BMC public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A Systematic Review and Multilevel Regression Analysis Reveals the Comorbidity Prevalence in Cancer.Cancer research · 2023Pooled it
- Social determinants of multimorbidity patterns: A systematic review.Frontiers in public health · 2023Pooled it
- An ageing biomarker signature predicts chronic disease cluster trajectories, physical function and mortality: validation in the TILDA and HRS cohorts.Age and ageing · 2026Article
- The structural roots of multimorbidity: social inequalities, health disparities, and systemic challenges in Southern Spain.International journal for equity in health · 2026Article
- Multimorbidity Patterns and Cluster Characteristics Among People Living with HIV in the Korean HIV/AIDS Cohort, 2006-2023.Public health weekly report · 2026Article
- A cross-national comparison of obesity using body mass index-for-age percentiles: results from the Canadian Longitudinal Study on Aging and the United States Health and Retirement Study.American journal of epidemiology · 2025Article
- Multimorbidity quantification from the perspective of precision management: challenges and strategies.Annals of medicine · 2025Review
- Cohort Profile Update: The Irish Longitudinal Study on Ageing (TILDA)-Waves 5 and 6.International journal of epidemiology · 2025Article
- Hobby engagement and all-cause and cause-specific mortality risk among people aged 50 years and older in 19 countries.Journal of global health · 2025Article
- The spatial analysis of multimorbidity in Thai Cohort Study.Archives of public health = Archives belges de sante publique · 2025Article
- Multimorbidity patterns and premature mortality in a prospective cohort: effect modifications by socioeconomic status and healthy lifestyles.BMC public health · 2025Article
- Uncovering bridging diseases in complex multimorbidity pathways: A network science approach.PloS one · 2025Article
- Sex- and age-specific multimorbidity networks in middle-aged inpatients: a network-based comparative study between China and the United Kingdom.Innovation in aging · 2025Article
- Europeans and Americans of European origin show differences between their biological pathways related to the major histocompatibility complex.Scientific reports · 2024Article
- Article
- Clustering by multiple long-term conditions and social care needs: a cross-sectional study among 10 026 older adults in England.Journal of epidemiology and community health · 2023Article
- Epidemiology, mortality, and health service use of local-level multimorbidity patterns in South Spain.Nature communications · 2023Article
- Bariatric Surgery Should Be Offered to Active-Duty Military Personnel: a Retrospective Study of the Canadian Armed Forces' Experience.Obesity surgery · 2023Article
- Multimorbidity Patterns and Their Association with Social Determinants, Mental and Physical Health during the COVID-19 Pandemic.International journal of environmental research and public health · 2022Observational
- Social inequalities in multimorbidity patterns in Europe: A multilevel latent class analysis using the European Social Survey (ESS).SSM - population health · 2022Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
backgroundIdentification of those who are most at risk of developing specific patterns of disease across different populations is required for directing public health policy. Here, we contrast prevalence and patterns of cross-national disease incidence, co-occurrence and related risk factors across population samples from the U.S., Canada, England and Ireland.
methodsParticipants (n = 62,111) were drawn from the US Health and Retirement Study (n = 10,858); the Canadian Longitudinal Study on Ageing (n = 36,647); the English Longitudinal Study of Ageing (n = 7938) and The Irish Longitudinal Study on Ageing (n = 6668). Self-reported lifetime prevalence of 10 medical conditions, predominant clusters of multimorbidity and their specific risk factors were compared across countries using latent class analysis.
resultsThe U.S. had significantly higher prevalence of multimorbid disease patterns and nearly all diseases when compared to the three other countries, even after adjusting for age, sex, BMI, income, employment status, education, alcohol consumption and smoking history. For the U.S. the most at-risk group were younger on average compared to Canada, England and Ireland. Socioeconomic gradients for specific disease combinations were more pronounced for the U.S., Canada and England than they were for Ireland. The rates of obesity trends over the last 50 years align with the prevalence of eight of the 10 diseases examined. While patterns of disease clusters and the risk factors related to each of the disease clusters were similar, the probabilities of the diseases within each cluster differed across countries.
conclusionsThis information can be used to better understand the complex nature of multimorbidity and identify appropriate prevention and management strategies for treating multimorbidity across countries.
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