Evidence map›Paper›PMID 34525872›Full record

ArticleCell transplantation

Preferable Transplant Site for Hepatocyte Transplantation in a Rat Model.

Hiroyuki Ogasawara, Akiko Inagaki, Ibrahim Fathi, Takehiro Imura, Hiroki Yamana, Yoshikatsu Saitoh, Muneyuki Matsumura, Kengo Fukuoka, Shigehito Miyagi, Yasuhiro Nakamura and 4 more

Open access · goldAbstract read
In one paragraph

Article in Cell transplantation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Scaffold implantationAnnals of surgical treatment and research · 2025
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  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Hiroyuki OgasawaraDepartment of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan.ORCID 0000-0003-3213-3783
Akiko InagakiDivision of Transplantation and Regenerative Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.
Ibrahim FathiDivision of Transplantation and Regenerative Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.
Takehiro ImuraDivision of Transplantation and Regenerative Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.
Hiroki YamanaDepartment of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan.
Yoshikatsu SaitohDepartment of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan.
Muneyuki MatsumuraDepartment of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan.
Kengo FukuokaDepartment of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan.
Shigehito MiyagiDepartment of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan.
Yasuhiro NakamuraDivision of Pathology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Sendai, Japan.
Kazuo OhashiLaboratory of Drug Development and Science, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan.
Michiaki UnnoDepartment of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan.
Takashi KameiDepartment of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan.
Masafumi GotoDepartment of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan.
Tohoku University · JPThe University of Osaka · JPTohoku Medical and Pharmaceutical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intraportal injection is regarded as the current standard procedure of hepatocyte transplantation (HTx). In islet transplantation, which shares many aspects with HTx, recent studies have clarified that instant blood-mediated inflammatory reaction (IBMIR), characterized by strong innate immune responses, can cause poor engraftment, so other transplant sites to avoid such a reaction have been established. Although IBMIR was reported to occur in HTx, few reports have evaluated alternative transplant sites for HTx. In this study, we sought to determine the optimum transplant site for HTx. Rat hepatocytes (1.0 × 10

Indexed as

AnimalsDisease Models, AnimalHepatocytesIslets of Langerhans TransplantationMaleRatsSpleenhepatocyte transplantationIVISportalspleentransplant site

Identifiers

PMID34525872
PMCPMC8450989
OpenAlexW3200939507

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.