Evidence map›Paper›PMID 34525841›Full record

ArticleStroke2022

Phenotypes of Chronic Covert Brain Infarction in Patients With First-Ever Ischemic Stroke: A Cohort Study.

Jan Vynckier, Johannes Kaesmacher, Joanna Marguerite Wardlaw, Laurent Roten, Morin Beyeler, Nebiyat Filate Belachew, Lorenz Grunder, David Julian Seiffge, Simon Jung, Jan Gralla and 7 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stroke, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 18 citations in OpenAlex.

  1. Observational
  2. Article
  3. Article
  4. Article
  5. Chronic cerebral infarctions and white matter lesions link to long-term survival after a first ischemic event: A cohort study.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2022
    Article
  6. Population-Based Prevalence of Infarctions on 3D Fluid-Attenuated Inversion Recovery (FLAIR) Imaging.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2022
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 2 institutions in 2 countries.

Jan Vynckier *Departments of Neurology (J.V., M.B., D.J.S., S.J., M.R.H., U.P., M.G., M.A., U.F., T.R.M.), Inselspital, Bern University Hospital, and University of Bern, Switzerland.ORCID 0000-0001-5338-961X
Johannes Kaesmacher *Diagnostic and Interventional Neuroradiology (J.K., N.F.B., L.G., J.G., T.D.), Inselspital, Bern University Hospital, and University of Bern, Switzerland.ORCID 0000-0002-9177-2289
Joanna Marguerite WardlawCentre for Clinical Brain Sciences (J.W.), University of Edinburgh, United Kingdom.ORCID 0000-0002-9812-6642
Laurent RotenCardiology (L.R.), Inselspital, Bern University Hospital, and University of Bern, Switzerland.
Morin BeyelerDepartments of Neurology (J.V., M.B., D.J.S., S.J., M.R.H., U.P., M.G., M.A., U.F., T.R.M.), Inselspital, Bern University Hospital, and University of Bern, Switzerland.ORCID 0000-0001-5911-7957
Nebiyat Filate BelachewDiagnostic and Interventional Neuroradiology (J.K., N.F.B., L.G., J.G., T.D.), Inselspital, Bern University Hospital, and University of Bern, Switzerland.ORCID 0000-0001-5285-5922
Lorenz GrunderDiagnostic and Interventional Neuroradiology (J.K., N.F.B., L.G., J.G., T.D.), Inselspital, Bern University Hospital, and University of Bern, Switzerland.ORCID 0000-0003-0511-8422
David Julian SeiffgeDepartments of Neurology (J.V., M.B., D.J.S., S.J., M.R.H., U.P., M.G., M.A., U.F., T.R.M.), Inselspital, Bern University Hospital, and University of Bern, Switzerland.ORCID 0000-0003-3890-3849
Simon JungDepartments of Neurology (J.V., M.B., D.J.S., S.J., M.R.H., U.P., M.G., M.A., U.F., T.R.M.), Inselspital, Bern University Hospital, and University of Bern, Switzerland.
Jan GrallaDiagnostic and Interventional Neuroradiology (J.K., N.F.B., L.G., J.G., T.D.), Inselspital, Bern University Hospital, and University of Bern, Switzerland.
Tomas DobrockyDiagnostic and Interventional Neuroradiology (J.K., N.F.B., L.G., J.G., T.D.), Inselspital, Bern University Hospital, and University of Bern, Switzerland.ORCID 0000-0002-6167-3343
Mirjam Rachel HeldnerDepartments of Neurology (J.V., M.B., D.J.S., S.J., M.R.H., U.P., M.G., M.A., U.F., T.R.M.), Inselspital, Bern University Hospital, and University of Bern, Switzerland.ORCID 0000-0002-3594-2159
Ulrike PrangeDepartments of Neurology (J.V., M.B., D.J.S., S.J., M.R.H., U.P., M.G., M.A., U.F., T.R.M.), Inselspital, Bern University Hospital, and University of Bern, Switzerland.
Martina Béatrice GoeldlinDepartments of Neurology (J.V., M.B., D.J.S., S.J., M.R.H., U.P., M.G., M.A., U.F., T.R.M.), Inselspital, Bern University Hospital, and University of Bern, Switzerland.ORCID 0000-0001-5800-116X
Marcel ArnoldDepartments of Neurology (J.V., M.B., D.J.S., S.J., M.R.H., U.P., M.G., M.A., U.F., T.R.M.), Inselspital, Bern University Hospital, and University of Bern, Switzerland.
Urs Fischer *Departments of Neurology (J.V., M.B., D.J.S., S.J., M.R.H., U.P., M.G., M.A., U.F., T.R.M.), Inselspital, Bern University Hospital, and University of Bern, Switzerland.ORCID 0000-0003-0521-4051
Thomas Raphael Meinel *Departments of Neurology (J.V., M.B., D.J.S., S.J., M.R.H., U.P., M.G., M.A., U.F., T.R.M.), Inselspital, Bern University Hospital, and University of Bern, Switzerland.ORCID 0000-0002-0647-9273
University Hospital of Bern · CHUK Dementia Research Institute · GB

Funding

Chief Scientist Office TCS/17/08Medical Research Council MR/J006971/1
6 · The paper itself

Abstract

background and purposeThe aim of this study was to assess the rate of chronic covert brain infarctions (CBIs) in patients with acute ischemic stroke (AIS) and to describe their phenotypes and diagnostic value.

methodsThis is a single-center cohort study including 1546 consecutive patients with first-ever AIS on magnetic resonance imaging imaging from January 2015 to December 2017. The main study outcomes were CBI phenotypes, their relative frequencies, location, and association with vascular risk factors.

resultsAny CBI was present in 574/1546 (37% [95% CI, 35%-40%]) of patients with a total of 950 CBI lesions. The most frequent locations of CBI were cerebellar in 295/950 (31%), subcortical supratentorial in 292/950 (31%), and cortical in 213/950 (24%). CBI phenotypes included lacunes (49%), combined gray and white matter lesions (30%), gray matter lesions (13%), and large subcortical infarcts (7%). Vascular risk profile and white matter hyperintensities severity (19% if no white matter hyperintensity, 63% in severe white matter hyperintensity,

conclusionsCBIs were present in more than a third of patients with first AIS. Their location and phenotypes as determined by MRI were different from previous studies using computed tomography imaging. Among patients suffering from AIS, those with additional CBI represent a vascular high-risk subgroup and the association of different phenotypes of CBIs with differing risk factor profiles potentially points toward discriminative AIS etiologies.

Indexed as

AgedAged, 80 and overAtrial FibrillationCerebellar DiseasesCerebral CortexCerebral InfarctionCohort StudiesFemaleGray MatterHumansIntracranial EmbolismIschemic StrokeMagnetic Resonance ImagingMaleMiddle AgedPhenotypeatrial fibrillationcohort studyischemic strokerisk factorswhite matter

Identifiers

PMID34525841
PMCPMC8785517
OpenAlexW3200815619

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.