Evidence map›Paper›PMID 34525838›Full record

Observational studyStroke2021

Baseline Characteristics of Patients With Cavernous Angiomas With Symptomatic Hemorrhage in Multisite Trial Readiness Project.

Helen Kim, Kelly D Flemming, Jeffrey A Nelson, Avery Lui, Jennifer J Majersik, Michael Dela Cruz, Joseph Zabramski, Odilette Trevizo, Giuseppe Lanzino, Atif Zafar and 19 more

Open access · greenAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Stroke, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Review
  6. Article
  7. Observational
  8. Article
  9. Review
  10. Article
  11. Article
  12. Impact of socioeconomics and race on clinical follow-up and trial enrollment and adherence in cerebral cavernous malformation.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2023
    Article
  13. Perfusion and permeability as diagnostic biomarkers of cavernous angioma with symptomatic hemorrhage.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors at 10 institutions in 2 countries.

Helen Kim *Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care (H.K., J.A.N., A.L.), University of California, San Francisco.ORCID 0000-0002-1937-354X
Kelly D Flemming *Department of Neurology (K.D.F.), Mayo Clinic, Rochester, MN.
Jeffrey A NelsonCenter for Cerebrovascular Research, Department of Anesthesia and Perioperative Care (H.K., J.A.N., A.L.), University of California, San Francisco.
Avery LuiCenter for Cerebrovascular Research, Department of Anesthesia and Perioperative Care (H.K., J.A.N., A.L.), University of California, San Francisco.ORCID 0000-0003-0935-2611
Jennifer J MajersikDepartment of Neurology, University of Utah, Salt Lake City (J.J.M., M.D.C.).
Michael Dela CruzDepartment of Neurology, University of Utah, Salt Lake City (J.J.M., M.D.C.).
Joseph ZabramskiDepartment of Neurosurgery, Barrow Neurological Institute, Phoenix, AZ (J.Z., O.T.).
Odilette TrevizoDepartment of Neurosurgery, Barrow Neurological Institute, Phoenix, AZ (J.Z., O.T.).
Giuseppe LanzinoDepartment of Neurosurgery (G.L.), Mayo Clinic, Rochester, MN.
Atif ZafarDepartment of Neurology, University of Toronto, Canada (A.Z.).ORCID 0000-0002-2738-5225
Michel TorbeyDepartment of Neurology (M.T.), University of New Mexico, Albuquerque.ORCID 0000-0001-8187-9683
Marc C MabrayDepartment of Radiology (M.C.M.), University of New Mexico, Albuquerque.ORCID 0000-0001-7355-6833
Myranda RobinsonDepartment of Neurosurgery (M.R.), University of New Mexico, Albuquerque.ORCID 0000-0002-5494-4627
Jared NarvidDepartment of Radiology and Biomedical Imaging (J.N., J.L.), University of California, San Francisco.
Janine LupoDepartment of Radiology and Biomedical Imaging (J.N., J.L.), University of California, San Francisco.
Richard E ThompsonDepartment of Biostatistics (R.E.T.), Johns Hopkins University, Baltimore, MD.
Daniel F HanleyBrain Injury Outcomes, Department of Neurology (D.F.H., N.M., K.T., N.O.), Johns Hopkins University, Baltimore, MD.
Nichol McBeeBrain Injury Outcomes, Department of Neurology (D.F.H., N.M., K.T., N.O.), Johns Hopkins University, Baltimore, MD.
Kevin TreineBrain Injury Outcomes, Department of Neurology (D.F.H., N.M., K.T., N.O.), Johns Hopkins University, Baltimore, MD.
Noeleen OstapkovichBrain Injury Outcomes, Department of Neurology (D.F.H., N.M., K.T., N.O.), Johns Hopkins University, Baltimore, MD.
Agnieszka StadnikDepartment of Neurosurgery (A. Stadnik, K.P., N.H., A. Shkoukani, J.C.-P., I.A.), University of Chicago, IL.
Kristina PiedadDepartment of Neurosurgery (A. Stadnik, K.P., N.H., A. Shkoukani, J.C.-P., I.A.), University of Chicago, IL.
Nicholas HobsonDepartment of Neurosurgery (A. Stadnik, K.P., N.H., A. Shkoukani, J.C.-P., I.A.), University of Chicago, IL.
Timothy CarrollDepartment of Diagnostic Radiology (T.C.), University of Chicago, IL.ORCID 0000-0003-2113-6284
Abdallah ShkoukaniDepartment of Neurosurgery (A. Stadnik, K.P., N.H., A. Shkoukani, J.C.-P., I.A.), University of Chicago, IL.ORCID 0000-0002-5058-9752
Julián Carrión-PenagosDepartment of Neurosurgery (A. Stadnik, K.P., N.H., A. Shkoukani, J.C.-P., I.A.), University of Chicago, IL.ORCID 0000-0002-5773-0966
Carolina Mendoza-PucciniDivision of Clinical Research (C.M.-P.), National Institute of Neurological Disorders and Stroke, Bethesda, MD.ORCID 0000-0002-3241-9303
James I KoenigDivision of Neuroscience (J.I.K.), National Institute of Neurological Disorders and Stroke, Bethesda, MD.ORCID 0000-0003-1930-6870
Issam AwadDepartment of Neurosurgery (A. Stadnik, K.P., N.H., A. Shkoukani, J.C.-P., I.A.), University of Chicago, IL.ORCID 0000-0003-1510-602X
University of Chicago · USJohns Hopkins University · USUniversity of California, San Francisco · USUniversity of New Mexico · USBarrow Neurological Institute · USMayo Clinic · USNational Institute of Neurological Disorders and Stroke · USUniversity of California System · USUniversity of Utah · USUniversity of Toronto · CA

Funding

Trial Readiness in Cavernous Angiomas with Symptomatic HemorrhageU01NS104157 · NINDS · UNIVERSITY OF CHICAGO · PI AWAD, ISSAM A · 2018 to 2022
$3.8M
NINDS NIH HHS U01 NS104157
6 · The paper itself

Abstract

background and purposeBrain cavernous angiomas with symptomatic hemorrhage (CASH) have a high risk of neurological disability from recurrent bleeding. Systematic assessment of baseline features and multisite validation of novel magnetic resonance imaging biomarkers are needed to optimize clinical trial design aimed at novel pharmacotherapies in CASH.

methodsThis prospective, multicenter, observational cohort study included adults with unresected, adjudicated brain CASH within the prior year. Six US sites screened and enrolled patients starting August 2018. Baseline demographics, clinical and imaging features, functional status (modified Rankin Scale and National Institutes of Health Stroke Scale), and patient quality of life outcomes (Patient-Reported Outcomes Measurement Information System-29 and EuroQol-5D) were summarized using descriptive statistics. Patient-Reported Outcomes Measurement Information System-29 scores were standardized against a reference population (mean 50, SD 10), and one-sample

resultsAs of May 2020, 849 patients were screened and 110 CASH cases enrolled (13% prevalence of trial eligible cases). The average age at consent was 46±16 years, 53% were female, 41% were familial, and 43% were brainstem lesions. At enrollment, ≥90% of the cohort had independent functional outcome (modified Rankin Scale score ≤2 and National Institutes of Health Stroke Scale score <5). However, perceived health problems affecting quality of life were reported in >30% of patients (EuroQol-5D). Patients had significantly worse Patient-Reported Outcomes Measurement Information System-29 scores for anxiety (

conclusionsThese baseline features will aid investigators in patient stratification and determining the most appropriate outcome measures for clinical trials of emerging pharmacotherapies in CASH.

Indexed as

AdultAgedBrain NeoplasmsCerebral HemorrhageCohort StudiesFemaleHemangioma, Cavernous, Central Nervous SystemHumansMagnetic Resonance ImagingMaleMiddle AgedNeuroimagingbiomarkersclinical trialintracranial hemorrhagemagnetic resonance imagingquality of lifevascular malformations

Identifiers

PMID34525838
PMCPMC8608704
OpenAlexW3199467522

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.