ArticleImmunity2021
Resident memory CD8
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Article in Immunity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers.
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99 citing papers in PubMed, 159 citations in OpenAlex.
- CXCL3 Antagonism Reverses Systemic Antitumor Immune Memory Impairment Associated With High Tumor Burden and Sensitizes Anti-PD-1 Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Role of pyroptosis in melanoma: Molecular mechanisms and therapeutic potentials.Apoptosis : an international journal on programmed cell death · 2026Review
- Clonal sharing and plasticity of follicular CD4 + T cells across lymph nodes and tumors in non-small cell lung cancer.Nature communications · 2026Article
- EID1 blockade potentiates immunosurveillance against cancer metastasis via FPR1-mediated DC-NK crosstalk.Science China. Life sciences · 2026Article
- PRDM15 inhibits responses of Tissue-Resident memory T cells by activating PVR/TIGIT axis to mediate gastric cancer immunosuppression.Journal of advanced research · 2026Article
- Tumor-resident T cells and dendritic cells form an in situ archetype during immunotherapy response in melanoma.Nature communications · 2026Article
- Lymphatic egress recycles tumor-experienced effector CD8 T cells to sustain immune surveillance.bioRxiv : the preprint server for biology · 2026Article
- The immunology of vitiligo.Nature reviews. Immunology · 2026Review
- Radiation as an immune modulator: mechanisms and implications for combination with immunotherapy.Nature reviews. Cancer · 2026Review
- Phenotypic Characterization and Prognostic Impact of CD103+ Tissue-Resident Memory T Cells in Diffuse Large B-cell Lymphoma.Cancer immunology research · 2026Article
- Cancer Stem Cells Shift Metabolite Acetyl-Coenzyme A to Abrogate the Differentiation of CD103Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Inhibitory receptor states, immune homeostasis and the benefit-risk boundary of cancer checkpoint blockade.Frontiers in immunology · 2026Review
- CD38Frontiers in oncology · 2026Article
- The Janus face of tissue-resident memory T cells: dual programming in tumor immune surveillance and autoimmune pathology.Frontiers in immunology · 2026Review
- Dimethyl itaconate suppresses dendritic cell and CD8BMC medicine · 2025Article
- Stem-like T cells: molecular regulation, functional diversity, and therapeutic implications across diseases.Journal of translational medicine · 2025Review
- Tissue-Resident Memory T Cells: Pioneering New Avenues in Cancer Immunotherapy.Cancer medicine · 2025Review
- CD40 agonist improves the therapeutic efficacy of irreversible electroporation ablation for metastatic melanoma by promoting unexpected CD8Cancer immunology, immunotherapy : CII · 2025Article
- TNC-targeted CAR-macrophage therapy alleviates liver fibrosis in mice.Military Medical Research · 2025Article
- Resident Memory T Cell in Metastatic Lymph Nodes Is Associated With Favorable Prognosis in Gastric Cancer Patients.Cancer science · 2025Article
39 more citing papers are in PubMed but not listed here.
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Authors and funding
24 authors at 5 institutions in 1 country.
Aleksey K MolodtsovDepartment of Microbiology and Immunology, The Geisel School of Medicine at Dartmouth, Lebanon, NH 03756, USA.
Nikhil KhatwaniDepartment of Microbiology and Immunology, The Geisel School of Medicine at Dartmouth, Lebanon, NH 03756, USA.
Jennifer L VellaDepartment of Microbiology and Immunology, The Geisel School of Medicine at Dartmouth, Lebanon, NH 03756, USA.
Kathryn A LewisNorris Cotton Cancer Center, The Geisel School of Medicine at Dartmouth, Lebanon, NH 03756, USA.
Yanding ZhaoDepartment of Molecular and Systems Biology, The Geisel School of Medicine at Dartmouth, Lebanon, NH 03756, USA.
Jichang HanDepartment of Microbiology and Immunology, The Geisel School of Medicine at Dartmouth, Lebanon, NH 03756, USA.
Delaney E SullivanDepartment of Microbiology and Immunology, The Geisel School of Medicine at Dartmouth, Lebanon, NH 03756, USA.
Tyler G SearlesDepartment of Microbiology and Immunology, The Geisel School of Medicine at Dartmouth, Lebanon, NH 03756, USA.
Nicholas K PreissDepartment of Microbiology and Immunology, The Geisel School of Medicine at Dartmouth, Lebanon, NH 03756, USA.
Tamer B ShabanehDepartment of Microbiology and Immunology, The Geisel School of Medicine at Dartmouth, Lebanon, NH 03756, USA.
Peisheng ZhangNorris Cotton Cancer Center, The Geisel School of Medicine at Dartmouth, Lebanon, NH 03756, USA.
Aaron R HawkesNorris Cotton Cancer Center, The Geisel School of Medicine at Dartmouth, Lebanon, NH 03756, USA.
Brian T MalikDepartment of Microbiology and Immunology, The Geisel School of Medicine at Dartmouth, Lebanon, NH 03756, USA.
Fred W KollingNorris Cotton Cancer Center, The Geisel School of Medicine at Dartmouth, Lebanon, NH 03756, USA.
Edward J UsherwoodDepartment of Microbiology and Immunology, The Geisel School of Medicine at Dartmouth, Lebanon, NH 03756, USA.
Sandra L WongDepartment of Surgery, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756, USA.
Joseph D PhillipsDepartment of Surgery, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756, USA.
Keisuke ShiraiDepartment of Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756, USA.
Christina V AngelesDepartment of Surgery, University of Michigan, Ann Arbor, MI 48109, USA.
Shaofeng YanDepartment of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756, USA.
Tyler J CurielDepartment of Medicine and Mays Cancer Center, University of Texas Health, San Antonio, TX 78229, USA.
Yina H HuangDepartment of Microbiology and Immunology, The Geisel School of Medicine at Dartmouth, Lebanon, NH 03756, USA; Norris Cotton Cancer Center, The Geisel School of Medicine at Dartmouth, Lebanon, NH 03756, USA; Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756, USA.
Chao ChengDepartment of Medicine, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address: chao.cheng@bcm.edu.
Mary Jo TurkDepartment of Microbiology and Immunology, The Geisel School of Medicine at Dartmouth, Lebanon, NH 03756, USA; Norris Cotton Cancer Center, The Geisel School of Medicine at Dartmouth, Lebanon, NH 03756, USA. Electronic address: mary.jo.turk@dartmouth.edu.
Dartmouth College · USDartmouth–Hitchcock Medical Center · USBaylor College of Medicine · USThe University of Texas Health Science Center at San Antonio · USUniversity of Michigan–Ann Arbor · US
Funding
Translational Engineering in Cancer (TEC)P30CA023108 · NCI · DARTMOUTH COLLEGE · PI Fred W Kolling IV · 1985 to 2026
$91.3MTISSUE CULTURE---COREP30CA054174 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Robin Jean Leach · 1991 to 2026
$59.1MIMMUNOBIOLOGY OF MYELOID AND LYMPHOID CELLST32AI007363 · NIAID · DARTMOUTH COLLEGE · PI Claudia V Jakubzick · 1990 to 2026
$9.5MTissue Resident memory T cell responses to cancerR01CA225028 · NCI · DARTMOUTH COLLEGE · PI Mary Jo Turk · 2018 to 2026
$4.9MMOTILITY FACTOR RECEPTORR01CA051714 · NCI · WAYNE STATE UNIVERSITY · PI RAZ, AVRAHAM · 1991 to 2012
$3.8M(PQ#3) Novel tumor intrinsic PD-L1 signals direct tumor immune cell infiltrationR01CA205965 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI REEVES, WILLIAM BRIAN · 2017 to 2021
$3.2M(PQ2) PD-L1/PD-1 signals in aged hosts undergoing cancer immunotherapyR01CA231325 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI CURIEL, TYLER J., SHEN-ORR, SHAI SHLOMO · 2018 to 2022
$3.1MTargeting VISTA eradicates large, established PD-1/CTLA-4 resistant tumorsR01CA214062 · NCI · DARTMOUTH COLLEGE · PI NOELLE, RANDOLPH J., TURK, MARY JO · 2017 to 2021
$2.8MSustaining Tissue Resident Memory T cellsR01CA254042 · NCI · DARTMOUTH COLLEGE · PI Yina Hsing Huang, Mary Jo Turk · 2022 to 2026
$2.6MComputational Identification of new candidate drugs for lung cancer treatmentR21CA227996 · NCI · BAYLOR COLLEGE OF MEDICINE · PI CHENG, CHAO, ONEGA, TRACY · 2019 to 2020
$397k10X Genomics Chromium Single-cell Sequencing to Expand Research At DartmouthS10OD025235 · OD · DARTMOUTH COLLEGE · PI TOMLINSON, CRAIG R · 2018 to 2018
$125kDefining a Transcriptional Signatures of Tissue-Resident T-cells in Melanoma through Single Cell RNA-seqF31CA232554 · NCI · DARTMOUTH COLLEGE · PI MOLODTSOV, ALEKSEY · 2018 to 2019
$90kNCI NIH HHS F31 CA232554NCI NIH HHS P30 CA023108NCI NIH HHS P30 CA054174NCI NIH HHS R01 CA051714NCI NIH HHS R01 CA205965NCI NIH HHS R01 CA214062NCI NIH HHS R01 CA225028NCI NIH HHS R01 CA231325NCI NIH HHS R01 CA254042NCI NIH HHS R21 CA227996NIAID NIH HHS T32 AI007363NIH HHS S10 OD025235
Abstract
The nature of the anti-tumor immune response changes as primary tumors progress and metastasize. We investigated the role of resident memory (Trm) and circulating memory (Tcirm) cells in anti-tumor responses at metastatic locations using a mouse model of melanoma-associated vitiligo. We found that the transcriptional characteristics of tumor-specific CD8
Indexed as
AnimalsCD8-Positive T-LymphocytesCutaneous Malignant MelanomaHumansImmunologic MemoryLymph NodesMelanomaMelanoma, ExperimentalMiceSkin NeoplasmsVitiligoCancerCD69CD8 T cellsCXCR6parabiosisscRNA-seqTCRTrmTRP-2vitiligo
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.