ReviewImmunity2021
The neuroimmune response during stress: A physiological perspective.
Review in Immunity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed.
- Contextual fear conditioning leads to hypo-innervation of the left ventricular myocardium in female but not male C57BL/6J mice.IBRO neuroscience reports · 2026Article
- Associations of Biological Aging With Perceived Stress in Patients With Head and Neck Cancer Undergoing Intensity Modulated Radiation Therapy: A Longitudinal Study.International journal of radiation oncology, biology, physics · 2026Article
- Hyperactive basolateral amygdala mediates comorbid anxiety in chronic rhinosinusitis.Journal of neuroinflammation · 2026Article
- Acute stress alleviates type 2 lung inflammation by restricting ILC2s through corticosterone-glucocorticoid receptor signaling.Cellular & molecular immunology · 2026Article
- Distinct host-pathogen and microbiome responses of aoudad (Ammotragus lervia) and bighorn sheep (Ovis canadensis) following exposure to Mycoplasma ovipneumoniae with or without co-exposure to leukotoxigenic Pasteurellaceae.BMC veterinary research · 2026Article
- Cortisol and C-reactive protein interact to predict depressive symptoms.Psychoneuroendocrinology · 2026Article
- Perceived Racial Stress Effects on Neuropsychological Functioning in African Americans are Mediated by the Brain's Reward/Safety SEEKING Systems via Neuroimmune and Neuroendocrine Pathways.Journal of racial and ethnic health disparities · 2026Article
- The past and future of integrated biopsychosocial whole-health perspectives in psychiatric rehabilitation.Psychiatric rehabilitation journal · 2026Review
- Sympathetic innervation of human cervical lymph nodes: A potential neuroimmunomodulatory target for the treatment of T-cell-driven autoimmune diseases like MS?Journal of anatomy · 2026Article
- Enteric nervous system and inflammatory bowel disease.Gastroenterology report · 2026Review
- What we get wrong about stress in sports psychology: an opinion.Frontiers in psychology · 2026Article
- How causal is "circular causality"?Frontiers in network physiology · 2026Article
- Connection and communication between the nervous and immune systems.Nature reviews. Immunology · 2025Review
- Opposing roles of microglial and macrophagic C3ar1 signaling in stress-induced synaptic and behavioral changes.Molecular psychiatry · 2025Article
- Long-Term Heat Stress Triggers Immune Activation and Cell Death Remodeling in the Brain of Largemouth Bass (Animals : an open access journal from MDPI · 2025Article
- Unraveling functional neurological disorder in pediatric populations: A systematic review of diagnosis, treatment, and outcomes.World journal of clinical pediatrics · 2025Article
- Neurodevelopmental origins of structural and psychomotor defects in CXCR4-linked primary immunodeficiency.Neuron · 2025Article
- Neuro-immune cross-talk in cancer.Nature reviews. Cancer · 2025Review
- Chronic stress-mediated dysregulations in inflammatory, immune and oxidative circuitry impairs the therapeutic response of methotrexate in experimental autoimmune disease models.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
- Association between a history of mental illness and the risk of systemic autoimmune rheumatic diseases: a nationwide, population-based case-control study.Clinical rheumatology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Stress is an essential adaptive response that enables the organism to cope with challenges and restore homeostasis. Different stressors require distinctive corrective responses in which immune cells play a critical role. Hence, effects of stress on immunity may vary accordingly. Indeed, epidemiologically, stress can induce either inflammation or immune suppression in an organism. However, in the absence of a conceptual framework, these effects appear chaotic, leading to confusion. Here, we examine how stressor diversity is imbedded in the neuroimmune axis. Stressors differ in the brain patterns they induce, diversifying the neuronal and endocrine mediators dispatched to the periphery and generating a wide range of potential immune effects. Uncovering this complexity and diversity of the immune response to different stressors will allow us to understand the involvement of stress in pathological conditions, identify ways to modulate it, and even harness the therapeutic potential embedded in an adaptive response to stress.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.