Evidence map›Paper›PMID 34525263›Full record

ArticleImmunity, inflammation and disease2021

Cytomegalovirus mismatch after heart transplantation: Impact of antiviral prophylaxis and intravenous hyperimmune globulin.

Moritz B Immohr, Payam Akhyari, Charlotte Böttger, Arash Mehdiani, Hannan Dalyanoglu, Ralf Westenfeld, Daniel Oehler, Igor Tudorache, Hug Aubin, Artur Lichtenberg and 1 more

Open access · goldAbstract read
In one paragraph

Article in Immunity, inflammation and disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Cytomegalovirus in the transplant setting: Where are we now and what happens next? A report from the International CMV Symposium 2021.Transplant infectious disease : an official journal of the Transplantation Society · 2022
    Review
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Moritz B ImmohrDepartment of Cardiac Surgery, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.ORCID 0000-0003-1051-8105
Payam AkhyariDepartment of Cardiac Surgery, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.ORCID 0000-0002-6452-8678
Charlotte BöttgerDepartment of Cardiac Surgery, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Arash MehdianiDepartment of Cardiac Surgery, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Hannan DalyanogluDepartment of Cardiac Surgery, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Ralf WestenfeldDepartment of Cardiology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Daniel OehlerDepartment of Cardiology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Igor TudoracheDepartment of Cardiac Surgery, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Hug AubinDepartment of Cardiac Surgery, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Artur LichtenbergDepartment of Cardiac Surgery, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Udo BoekenDepartment of Cardiac Surgery, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Heinrich Heine University Düsseldorf · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveCytomegalovirus (CMV) infections are correlated with complications following heart transplantation (HTx) and impaired outcome. The impact of a serologic mismatch between donor and recipient and the necessity of prophylactic virostatic medication is still a matter of concern.

methodsWe retrospectively reviewed all patients that underwent HTx between 2010 and 2020 in our department. The recipients (n = 176) could be categorized into four risk groups depending on their serologic CMV matching (D

resultsIncidence of postoperative morbidity such as primary graft dysfunction, neurological events, infections, and graft rejection were comparable between all groups (p > .05). However, the incidence of postoperative acute kidney injury with hemodialysis was by trend increased in the D

conclusionsSeropositive recipients carry an important risk for CMV-DNAemia. However, we did not observe differences in perioperative morbidity and mortality regarding CMV matching, which might be related to regularly administer prophylactic virostatics and additional CMV-IVIG for risk constellations. For high-risk constellation, long-term application of CMV-IVIG during the first year after transplant may be beneficial.

Indexed as

CytomegalovirusHeart TransplantationAntibodies, ViralAntiviral AgentsHumansRetrospective StudiesAntibodies, ViralAntiviral AgentsCMV-DNAemiacytomegalovirusganciclovirheart transplantationintravenous hyperimmune globulinvalganciclovir

Identifiers

PMID34525263
PMCPMC8589400
OpenAlexW3199557810

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.