Evidence map›Paper›PMID 34525232›Full record

ArticleActa paediatrica (Oslo, Norway : 1992)2021

COVID-19 among children seeking primary paediatric care with signs of an acute infection.

Sebastian Hoehl, Felix Schneider, Martin Eckrich, Tim Ole Gründler, Pera Silvija Jerkic, Geri Lichtenstein, Birgit Melcher, Hansjörg Melcher, Ralf Moebus, Barbara Mühlfeld and 8 more

Open access · hybridAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta paediatrica (Oslo, Norway : 1992), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 4 institutions in 1 country.

Sebastian HoehlInstitute of Medical Virology, Goethe University Frankfurt, Frankfurt am Main, Germany.ORCID 0000-0002-5100-9385
Felix SchneiderInstitute of Medical Virology, Goethe University Frankfurt, Frankfurt am Main, Germany.
Martin EckrichPraxisgemeinschaft für Kinder- und Jugendmedizin Dres, Martin Eckrich & Tim Gründler, Offenbach-Rumpenheim, Germany.
Tim Ole GründlerPraxisgemeinschaft für Kinder- und Jugendmedizin Dres, Martin Eckrich & Tim Gründler, Offenbach-Rumpenheim, Germany.
Pera Silvija JerkicGemeinschaftspraxis Dr.med. Silvija Jerkic und Dr.med. Christian Walter, Allergologie, Pädiatrische Pneumologie, Kinderheilkunde und Jugendmedizin, Bad Homburg v.d.H, Germany.
Geri LichtensteinKinder & Jugendarzt Dr. med. Geri Lichtenstein, Eschborn, Germany.
Birgit MelcherGemeinschaftspraxis Kinder- und Jugendmedizin Dres. Birgit und Hansjörg Melcher, Bad Soden am Taunus, Germany.
Hansjörg MelcherGemeinschaftspraxis Kinder- und Jugendmedizin Dres. Birgit und Hansjörg Melcher, Bad Soden am Taunus, Germany.
Ralf MoebusKinder- und Jugendarzt Dr. Ralf Moebus, Bad Homburg v.d.H, Germany.
Barbara MühlfeldGemeinschaftspraxis Dr.med. Silvija Jerkic und Dr.med. Christian Walter, Allergologie, Pädiatrische Pneumologie, Kinderheilkunde und Jugendmedizin, Bad Homburg v.d.H, Germany.
Ilonka RiegerGemeinschaftspraxis Dr.med. Silvija Jerkic und Dr.med. Christian Walter, Allergologie, Pädiatrische Pneumologie, Kinderheilkunde und Jugendmedizin, Bad Homburg v.d.H, Germany.
Beate Seger-FritzKinderarztpraxis Seger-Fritz, Frankfurt am Main, Germany.
Stefan SgollKinderarztpraxis Dr. Sgoll, Gründau, Germany.
Christian WalterGemeinschaftspraxis Dr.med. Silvija Jerkic und Dr.med. Christian Walter, Allergologie, Pädiatrische Pneumologie, Kinderheilkunde und Jugendmedizin, Bad Homburg v.d.H, Germany.
Sebastian WernerKinderarztpraxis Dr. Sgoll, Gründau, Germany.
Eva HerrmannInstitute of Biostatistics and Mathematical Modeling, Goethe University Frankfurt, Frankfurt am Main, Germany.
Annemarie BergerInstitute of Medical Virology, Goethe University Frankfurt, Frankfurt am Main, Germany.
Sandra CiesekInstitute of Medical Virology, Goethe University Frankfurt, Frankfurt am Main, Germany.ORCID 0000-0002-1802-7565
Goethe University Frankfurt · DEPraxis für Humangenetik · DEDeutsche Akademie für Kinder- und Jugendmedizin · DEIndustrial Union of Metalworkers · DE

Funding

Roche Diagnostics
6 · The paper itself

Abstract

aimIt can be challenging to distinguish COVID-19 in children from other common infections. We set out to determine the rate at which children consulting a primary care paediatrician with an acute infection are infected with SARS-CoV-2 and to compare distinct findings.

methodIn seven out-patient clinics, children aged 0-13 years with any new respiratory or gastrointestinal symptoms and presumed infection were invited to be tested for SARS-CoV-2. Factors that were correlated with testing positive were determined. Samples were collected from 25 January 2021 to 01 April 2021.

resultsSeven hundred and eighty-three children participated in the study (median age 3 years and 0 months, range 1 month to 12 years and 11 months). Three hundred and fifty-eight were female (45.7%). SARS-CoV-2 RNA was detected in 19 (2.4%). The most common symptoms in children with as well as without detectable SARS-CoV-2 RNA were rhinitis, fever and cough. Known recent exposure to a case of COVID-19 was significantly correlated with testing positive, but symptoms or clinical findings were not.

conclusionCOVID-19 among the children with symptoms of an acute infection was uncommon, and the clinical presentation did not differ significantly between children with and without evidence of an infection with SARS-CoV-2.

Indexed as

COVID-19ChildFemaleFeverHumansInfantPrimary Health CareRNA, ViralSARS-CoV-2RNA, ViralCOVID-19influenzaout-patient paediatricsrespiratory tract infectionSARS-CoV-2

Identifiers

PMID34525232
PMCPMC8653082
OpenAlexW3199227030

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.