ArticleThe New phytologist2021
Strigolactone biosynthesis catalyzed by cytochrome P450 and sulfotransferase in sorghum.
Article in The New phytologist, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 51 citations in OpenAlex.
- Genome-wide association study identifies consistent genomic loci for yield and nutritional quality in Ethiopian sorghum landraces.The plant genome · 2026Article
- Characterization and Quantification of Strigolactones in Root Exudates.Methods in molecular biology (Clifton, N.J.) · 2026Article
- A powerful molecular marker to detect mutations at sorghum LOW GERMINATION STIMULANT 1.The plant genome · 2025Article
- Chemistry and chemical biology tools contributing to the discovery and functional characterization of strigolactones.Frontiers in plant science · 2025Review
- Insights into stereoselective ring formation in canonical strigolactone: Identification of a dirigent domain-containing enzyme catalyzing orobanchol synthesis.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Cracking the enigma: understanding strigolactone signalling in the rhizosphere.Journal of experimental botany · 2024Review
- Strigolactones and Shoot Branching: What Is the Real Hormone and How Does It Work?Plant & cell physiology · 2023Review
- A Stereoselective Strigolactone Biosynthesis Catalyzed by a 2-Oxoglutarate-Dependent Dioxygenase in Sorghum.Plant & cell physiology · 2023Article
- Synthesis of Carlactone Derivatives to Develop a Novel Inhibitor of Strigolactone Biosynthesis.ACS omega · 2023Article
- Ancestral sequence reconstruction of the CYP711 family reveals functional divergence in strigolactone biosynthetic enzymes associated with gene duplication events in monocot grasses.The New phytologist · 2022Article
- Article
- Production and stably maintenance of strigolactone by transient expression of biosynthetic enzymes inFrontiers in plant science · 2022Article
- Structure Elucidation and Biosynthesis of Orobanchol.Frontiers in plant science · 2022Review
- A Unique Sulfotransferase-Involving Strigolactone Biosynthetic Route in Sorghum.Frontiers in plant science · 2021Article
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Authors and funding
12 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Root parasitic plants such as Striga, Orobanche, and Phelipanche spp. cause serious damage to crop production world-wide. Deletion of the Low Germination Stimulant 1 (LGS1) gene gives a Striga-resistance trait in sorghum (Sorghum bicolor). The LGS1 gene encodes a sulfotransferase-like protein, but its function has not been elucidated. Since the profile of strigolactones (SLs) that induce seed germination in root parasitic plants is altered in the lgs1 mutant, LGS1 is thought to be an SL biosynthetic enzyme. In order to clarify the enzymatic function of LGS1, we looked for candidate SL substrates that accumulate in the lgs1 mutants and performed in vivo and in vitro metabolism experiments. We found the SL precursor 18-hydroxycarlactonoic acid (18-OH-CLA) is a substrate for LGS1. CYP711A cytochrome P450 enzymes (SbMAX1 proteins) in sorghum produce 18-OH-CLA. When LGS1 and SbMAX1 coding sequences were co-expressed in Nicotiana benthamiana with the upstream SL biosynthesis genes from sorghum, the canonical SLs 5-deoxystrigol and 4-deoxyorobanchol were produced. This finding showed that LGS1 in sorghum uses a sulfo group to catalyze leaving of a hydroxyl group and cyclization of 18-OH-CLA. A similar SL biosynthetic pathway has not been found in other plant species.
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