ArticleThe Journal of comparative neurology2022
Cellular resolution anatomical and molecular atlases for prenatal human brains.
Article in The Journal of comparative neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24 citing papers in PubMed, 34 citations in OpenAlex.
- CytoCLIP: Learning Cytoarchitectural Characteristics in Developing Human Brain Using Contrastive Language Image Pre-Training.Neuroinformatics · 2026Article
- A novel PTEN variant causing hemimegalencephaly and focal nodular heterotopias in the developing human brain.Epilepsia · 2026Article
- Transcriptomic divergence of network hubs in the prenatal human brain.Communications biology · 2025Article
- Article
- Morphometry of the Human Ventral Germinal Matrix during Fetal Development.Bulletin of experimental biology and medicine · 2025Article
- DHARANI: A 3D Developing Human-Brain Atlas Resource to Advance Neuroscience Internationally Integrated Multimodal Imaging and High-Resolution Histology of the Second Trimester.The Journal of comparative neurology · 2025Article
- Development of the early fetal human thalamus: from a protomap to emergent thalamic nuclei.Frontiers in neuroanatomy · 2025Article
- Brain-wide connections of the parvicellular subdivision of the basolateral and basomedial amygdaloid nuclei in the rats.Frontiers in neural circuits · 2025Article
- Development of the basic architecture of neocortical circuitry in the human fetus as revealed by the coupling spatiotemporal pattern of synaptogenesis along with microstructure and macroscale in vivo MR imaging.Brain structure & function · 2024Article
- Molecular signatures of cortical expansion in the human foetal brain.Nature communications · 2024Article
- A polarized FGF8 source specifies frontotemporal signatures in spatially oriented cell populations of cortical assembloids.Nature methods · 2024Article
- Spatial Single-cell Analysis Decodes Cortical Layer and Area Specification.bioRxiv : the preprint server for biology · 2024Article
- Lamination, Borders, and Thalamic Projections of the Primary Visual Cortex in Human, Non-Human Primate, and Rodent Brains.Brain sciences · 2024Review
- Molecular signatures of cortical expansion in the human fetal brain.bioRxiv : the preprint server for biology · 2024Article
- Comparison of the connectivity of the posterior intralaminar thalamic nucleus and peripeduncular nucleus in rats and mice.Frontiers in neural circuits · 2024Article
- The histological development of the fetal human inferior colliculus during the second trimester.Frontiers in neuroanatomy · 2024Article
- A novel subdivision of the bed nucleus of stria terminalis in monkey, rat, and mouse brains.The Journal of comparative neurology · 2023Article
- Pattern of ventral temporal lobe interconnections in rhesus macaques.The Journal of comparative neurology · 2023Article
- Neuromorphological Atlas of Human Prenatal Brain Development: White Paper.Life (Basel, Switzerland) · 2023Article
- Expression of the schizophrenia associated geneFrontiers in neuroscience · 2023Article
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Authors and funding
30 authors at 3 institutions in 2 countries.
Funding
Abstract
Increasing interest in studies of prenatal human brain development, particularly using new single-cell genomics and anatomical technologies to create cell atlases, creates a strong need for accurate and detailed anatomical reference atlases. In this study, we present two cellular-resolution digital anatomical atlases for prenatal human brain at postconceptional weeks (PCW) 15 and 21. Both atlases were annotated on sequential Nissl-stained sections covering brain-wide structures on the basis of combined analysis of cytoarchitecture, acetylcholinesterase staining, and an extensive marker gene expression dataset. This high information content dataset allowed reliable and accurate demarcation of developing cortical and subcortical structures and their subdivisions. Furthermore, using the anatomical atlases as a guide, spatial expression of 37 and 5 genes from the brains, respectively, at PCW 15 and 21 was annotated, illustrating reliable marker genes for many developing brain structures. Finally, the present study uncovered several novel developmental features, such as the lack of an outer subventricular zone in the hippocampal formation and entorhinal cortex, and the apparent extension of both cortical (excitatory) and subcortical (inhibitory) progenitors into the prenatal olfactory bulb. These comprehensive atlases provide useful tools for visualization, segmentation, targeting, imaging, and interpretation of brain structures of prenatal human brain, and for guiding and interpreting the next generation of cell census and connectome studies.
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