Evidence map›Paper›PMID 34525210›Full record

ArticleInflammatory bowel diseases2021

Expanding Contributions of Monogenic Very Early Onset Inflammatory Bowel Disease.

Jodie Ouahed

Open access · greenAbstract readEditorialComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Inflammatory bowel diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 89% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Jodie OuahedDivision of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Boston Children's Hospital, and Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0002-2011-6209
Boston Children's Hospital · US

Funding

Role of Interferon lambda signaling in mucosal homeostasis and infantile-onset inflammatory bowel diseaseK08DK122133 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI OUAHED, JODIE · 2020 to 2024
$896k
National Institute Of Diabetes And Digestive And Kidney Diseases of the National Institutes of Health K08DK122133NIDDK NIH HHS K08 DK122133NIDDK NIH HHS K08DK122133NIH HHS K08DK122133
6 · The paper itself

Abstract

Currently over 70 genes known to be causative in very early onset inflammatory bowel disease (VEOIBD) have been identified. In the current issue of Inflammatory Bowel Diseases, 2 articles describing monogenetic forms of VEOIBD are highlighted. One describes a patient with life-threatening VEOIBD and a mutation in ITGA6, illustrating the importance of the epithelial barrier in maintaining mucosal homeostasis. The other describes the presentation and management of 10 patients with VEOIBD secondary to damaging mutations in MVK, resulting in mevalonate kinase deficiency. Though most monogenic causes of VEOIBD remain "private," understanding the different categories of pathways affected in children with VEOIBD is critical and has already resulted in invaluable insight in the management of patients with VEOIBD and may hold strong implications for the care of IBD overall.

Indexed as

ColitisInflammatory Bowel DiseasesAge of OnsetChildHumansIntestinesMutationgeneticsmonogenicvery early onset inflammatory bowel disease

Identifiers

PMID34525210
PMCPMC8528145
OpenAlexW3200508211

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.