Evidence map›Paper›PMID 34525186›Full record

ArticleInflammatory bowel diseases2022

Intestinal Ultrasound to Evaluate Treatment Response During Pregnancy in Patients With Inflammatory Bowel Disease.

Floris De Voogd, Harshad Joshi, Elsa Van Wassenaer, Steven Bots, Geert D'Haens, Krisztina Gecse

Abstract read
In one paragraph

Article in Inflammatory bowel diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. The Emerging Role of Ultrasonography in Ulcerative Colitis.Diagnostics (Basel, Switzerland) · 2026
    Review
  3. Update on Pregnancy in Inflammatory Bowel Disease.Gastroenterology & hepatology · 2026
    Article
  4. Article
  5. Review
  6. Conception, pregnancy and inflammatory bowel disease-Current concepts for the practising clinician.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2026
    Review
  7. Article
  8. Article
  9. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Floris De VoogdAmsterdam University Medical Center, Department of Gastroenterology and Hepatology, University of Amsterdam, Amsterdam, the Netherlands.ORCID 0000-0003-4058-252X
Harshad JoshiSir H. N. Reliance Hospital and Research Centre, Mumbai, India.
Elsa Van WassenaerAmsterdam University Medical Center, Department of Pediatric Gastroenterology, Emma Children's Hospital, University of Amsterdam, Amsterdam, the Netherlands.
Steven BotsAmsterdam University Medical Center, Department of Gastroenterology and Hepatology, University of Amsterdam, Amsterdam, the Netherlands.
Geert D'HaensAmsterdam University Medical Center, Department of Gastroenterology and Hepatology, University of Amsterdam, Amsterdam, the Netherlands.
Krisztina GecseAmsterdam University Medical Center, Department of Gastroenterology and Hepatology, University of Amsterdam, Amsterdam, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionActive disease in inflammatory bowel disease patients during pregnancy is associated with poor maternal and fetal outcomes. Objective evaluation of disease activity is a core strategy in IBD, and during pregnancy noninvasive modalities are preferred. We aimed to evaluate feasibility and accuracy of intestinal ultrasound (IUS) to objectify disease activity throughout pregnancy.

methodsPregnant patients with known IBD were included and followed throughout pregnancy for clinical disease activity, with fecal calprotectin (FCP) and with IUS every trimester. Feasibility of IUS was assessed for all colonic segments and terminal ileum (TI). Intestinal ultrasound outcomes to detect active disease and treatment response were compared with clinical scores combined with FCP.

resultsIn total, 38 patients (22 CD, 16 UC) were included, with 27 patients having serial IUS. Feasibility of IUS decreases significantly in third trimester for TI (first vs third trimester: 91.3% vs 21.7%, P < .0001) and sigmoid (first vs third trimester: 95.6% vs 69.5%, P = .023). Intestinal ultrasound activity showed moderate to strong correlation with clinical activity (r = 0.60, P < .0001) and FCP (r = 0.73, P < .0001). Throughout pregnancy, IUS distinguished active from quiescent disease with 84% sensitivity and 98% specificity according to FCP combined with clinical activity. IUS showed disease activity in >1 segment in 52% of patients and detected treatment response with 80% sensitivity and 92% specificity.

conclusionsIUS is feasible and accurate throughout pregnancy, although visualization of the sigmoid and TI decreases in the third trimester. IUS provides objective information on disease activity, extent, and treatment response, even during second and third trimester, and offers a noninvasive strategy to closely monitor patients during pregnancy.

Indexed as

Inflammatory Bowel DiseasesFecesFemaleHumansIntestinesLeukocyte L1 Antigen ComplexPregnancyUltrasonographyLeukocyte L1 Antigen Complexinflammatory bowel diseaseintestinal ultrasoundnoninvasive treatment monitoringpregnancy

Identifiers

PMID34525186
PMCPMC9247844

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.