ArticleEndocrine connections2021
Can waist circumference be a predictor of bone mineral density independent of BMI in middle-aged adults?
Article in Endocrine connections, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 39 citations in OpenAlex.
- Prevalence, risk factors and adverse health outcomes of osteosarcopenia in middle-aged and older adults with type 2 diabetes mellitus-a scoping review.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Review
- Association of body composition with bone mineral density and fracture in diabetic elderly: Results from AHAP study.Caspian journal of internal medicine · 2026Article
- The Association Between Waist Circumference and the Risk of Osteoporosis in Non-overweight US Adults.Indian journal of orthopaedics · 2025Article
- The association between lipid accumulation products and bone mineral density in U.S. Adults, a nationally representative cross-sectional study.Scientific reports · 2025Article
- Association between a body shape index and bone mineral density in US adults based on NHANES data.Scientific reports · 2025Article
- Correlation of body compositions and bone mineral density in postmenopausal women with different body mass index.Frontiers in endocrinology · 2025Article
- The association between relative fat mass (RFM) and lumbar bone density in US adults: Insight from 2011-2018 NHANES.PloS one · 2025Article
- Saturation Effect of Lipid Accumulation Product (LAP) Index on Spinal Bone Mineral Density: A Population-Based Study.Calcified tissue international · 2024Article
- Lipid accumulation product, poverty income ratio, and bone mineral density in U.S. adults: a mediation analysis based on NHANES (2009-2020).Frontiers in nutrition · 2024Article
- Weight change patterns across adulthood in relation to osteoporosis and fracture among non-obese individuals.Archives of osteoporosis · 2023Article
- Bone mineral density saturation as influenced by the visceral adiposity index in adults older than 20 years: a population-based study.Lipids in health and disease · 2023Article
- A cross-sectional study from NHANES found a positive association between obesity with bone mineral density among postmenopausal women.BMC endocrine disorders · 2023Article
- Osteoporosis Risk in Hemodialysis Patients: The Roles of Gender, Comorbidities, Biochemical Parameters, Health and Diet Literacy.Nutrients · 2022Article
- Environmental and personal factors for osteoporosis or osteopenia from a large health check-up database: a retrospective cohort study in Taiwan.BMC public health · 2022Article
- The causal relationship between abdominal obesity and lower bone mineral density: A two-sample mendelian randomization study.Frontiers in genetics · 2022Article
- A negative association between total cholesterol and bone mineral density in US adult women.Frontiers in nutrition · 2022Article
- The Saturation Effect of Obesity on Bone Mineral Density for Older People: The NHANES 2017-2020.Frontiers in endocrinology · 2022Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundObesity and osteoporosis are major public health issues globally. The prevalence of these two diseases prompts the need to better understand the relationship between them. Previous studies, however, have yielded controversial findings on this issue. Therefore, our aim in this study was to evaluate the independent association between waist circumference (WC), as a marker of obesity, and the bone mineral density (BMD) of the lumbar spine among middle-aged adults using data from the National Health and Nutrition Examination Survey (NHANES).
methodsOur analysis was based on NHANES data from 2011 to 2018, including 5084 adults, 40-59 years of age. A weighted multiple linear regression analysis was used to evaluate the association between WC and lumbar BMD, with smooth curve fitting performed for non-linearities.
resultsAfter adjusting for BMI and other potential confounders, WC was negatively associated with lumbar BMD in men (β = -2.8, 95% CI: -4.0 to -1.6) and premenopausal women (β = -2.6, 95% CI: -4.1 to -1.1). On subgroup analysis stratified by BMI, this negative association was more significant in men with a BMI ≥30 kg/m2 (β = -4.1, 95% CI: -6.3 to -2.0) and in pre- and postmenopausal women with a BMI <25 kg/m2 (premenopausal women: β= -5.7, 95% CI: -9.4 to-2.0; postmenopausal women: β=-5.6, 95% CI: -9.7 to -1.6). We further identified an inverted U-shaped relationship among premenopausal women, with a point of inflection at WC of 80 cm.
conclusionsOur study found an inverse relationship between WC and lumbar BMD in middle-aged men with BMI ≥30 kg/m2, and women with BMI <25 kg/m2.
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