Evidence map›Paper›PMID 34524914›Full record

ArticleJournal of virology2021

Infection of Glia by Human Pegivirus Suppresses Peroxisomal and Antiviral Signaling Pathways.

M A L Doan, A Roczkowsky, M Smith, G Blevins, F K H van Landeghem, B B Gelman, W G Branton, J T Stapleton, T C Hobman, C Power

Abstract read
In one paragraph

Article in Journal of virology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. The Blood Virome: A new frontier in biomedical science.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2024
    Review
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

M A L DoanNeuroscience and Mental Health Institute, University of Albertagrid.17089.37, Edmonton, Alberta, Canada.
A RoczkowskyDepartment of Medicine, University of Albertagrid.17089.37, Edmonton, Alberta, Canada.
M SmithDepartment of Medicine, University of Albertagrid.17089.37, Edmonton, Alberta, Canada.
G BlevinsDepartment of Medicine, University of Albertagrid.17089.37, Edmonton, Alberta, Canada.
F K H van LandeghemDepartment of Laboratory Medicine & Pathology, University of Albertagrid.17089.37, Edmonton, Alberta, Canada.
B B GelmanDepartment of Pathology, University of Texas Medical Branch, Galveston, Texas, USA.
W G BrantonDepartment of Medicine, University of Albertagrid.17089.37, Edmonton, Alberta, Canada.
J T StapletonDepartment of Internal Medicine, University of Iowa, Iowa City, Iowa, USA.
T C HobmanDepartment of Cell Biology, University of Albertagrid.17089.37, Edmonton, Alberta, Canada.ORCID 0000-0002-5744-3545
C PowerNeuroscience and Mental Health Institute, University of Albertagrid.17089.37, Edmonton, Alberta, Canada.ORCID 0000-0002-5131-9711

Funding

The Manhattan HIV Brain BankU24MH100931 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MORGELLO, SUSAN · 2013 to 2023
$14.0M
California NeuroAIDS Tissue NetworkU24MH100928 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ACHIM, CRISTIAN L, MOORE, DAVID J · 2013 to 2023
$13.9M
NATIONAL NEUROLOGICAL AIDS BANKU24MH100929 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SINGER, ELYSE J · 2013 to 2023
$12.5M
Texas NeuroAIDS Research CenterU24MH100930 · NIMH · UNIVERSITY OF TEXAS MED BR GALVESTON · PI GELMAN, BENJAMIN B. · 2013 to 2023
$12.1M
NNTC Data Coordinating CenterU24MH100925 · NIMH · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI FOX, HOWARD S, SHERMAN, SETH · 2013 to 2022
$9.5M
NIMH NIH HHS U24 MH100925NIMH NIH HHS U24 MH100928NIMH NIH HHS U24 MH100929NIMH NIH HHS U24 MH100930NIMH NIH HHS U24 MH100931
6 · The paper itself

Abstract

Human pegivirus (HPgV) infects peripheral leukocytes but was recently shown to be a neurotropic virus associated with leukoencephalitis in humans. In the present study, we investigated the neural cell tropism of HPgV as well as its effects on host immune responses. HPgV wild type (WT) and a mutant virus with a deletion in the HPgV

Indexed as

Antiviral AgentsAstrocytesBrainFlaviviridae InfectionsGene ExpressionHumansMicrogliaNeurogliaPegivirusPhylogenyRNA, ViralSignal TransductionViral Nonstructural ProteinsAntiviral AgentsRNA, ViralViral Nonstructural Proteinsgliahuman pegivirusperoxisometype I interferon

Identifiers

PMID34524914
PMCPMC8577381

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.