Evidence map›Paper›PMID 34524905›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2021

Therapeutic effects of high molecular weight hyaluronic acid in severe

Xiwen Zhang, Shinji Sugita, Airan Liu, Yoshifumi Naito, Wonjung Hwang, Haibo Qiu, Atsuhiro Sakamoto, Teiji Sawa, Michael A Matthay, Jae-Woo Lee

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Hyaluronan Ameliorates Viral Pneumonia in Mice and Humans by Inhibiting Transcription Factor E2F1.American journal of respiratory cell and molecular biology · 2026
    Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Xiwen ZhangDepartment of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China.
Shinji SugitaDepartment of Anesthesiology, Nippon Medical School, Tokyo, Japan.
Airan LiuDepartment of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China.
Yoshifumi NaitoDepartment of Anesthesiology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Wonjung HwangDepartments of Anesthesiology, Medicine, and Cardiovascular Research Institute, University of California, San Francisco, California.
Haibo QiuDepartment of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China.
Atsuhiro SakamotoDepartment of Anesthesiology, Nippon Medical School, Tokyo, Japan.
Teiji SawaDepartment of Anesthesiology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Michael A MatthayDepartments of Anesthesiology, Medicine, and Cardiovascular Research Institute, University of California, San Francisco, California.ORCID 0000-0003-3039-8155
Jae-Woo LeeDepartments of Anesthesiology, Medicine, and Cardiovascular Research Institute, University of California, San Francisco, California.ORCID 0000-0002-6521-8647
University of California, San Francisco · USKyoto Prefectural University of Medicine · JPZhongda Hospital Southeast University · CNNippon Medical School · JP

Funding

Precision Medicine in the Acute Respiratory Distress SyndromeR35HL140026 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CALFEE, CAROLYN · 2018 to 2024
$6.8M
Human Mesenchymal Stem Cell Microvesicles for the Treatment of Acute Lung InjuryR01HL113022 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LEE, JAE WOO · 2012 to 2020
$4.1M
NOVEL PARACRINE MECHANISMS FOR CELL-BASED THERAPY OF INJURED LUNGSR01HL134828 · NHLBI · UNIVERSITY OF TEXAS HLTH CTR AT TYLER · PI JI, HONG-LONG · 2017 to 2025
$3.4M
Therapeutic Use of High Molecular Weight Hyaluronic Acid in Acute Lung Injury Following Severe Bacterial Pneumonia or SepsisR01HL148781 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ENKHBAATAR, PERENLEI, LEE, JAE WOO · 2020 to 2023
$3.2M
HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) 134828HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) 140026NHLBI NIH HHS R01 HL113022NHLBI NIH HHS R01 HL148781
6 · The paper itself

Abstract

We previously reported that extracellular vesicles (EVs) released during

Indexed as

Acute Lung InjuryAdultExtracellular VesiclesFemaleHumansHyaluronic AcidLungMaleMiddle AgedMonocytesNeutrophilsOrgan Culture TechniquesPhagocytosisPneumonia, BacterialPseudomonas aeruginosaPseudomonas InfectionsHyaluronic Acidacute lung injuryalveolar fluid clearanceextracellular vesicleshyaluronic acidPseudomonas aeruginosa pneumonia

Identifiers

PMID34524905
PMCPMC8616617
OpenAlexW3200063902

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.