Evidence map›Paper›PMID 34524889›Full record

ArticleJournal of clinical microbiology2021

Evaluation of Antimicrobial Susceptibility Testing Methods for Burkholderia cenocepacia and Burkholderia multivorans Isolates from Cystic Fibrosis Patients.

Holly K Huse, Mark J Lee, Mandy Wootton, Susan E Sharp, Maria Traczewski, John J LiPuma, Peter Jorth

Abstract read
In one paragraph

Article in Journal of clinical microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Is it okay to use a commercially available AST forJournal of clinical microbiology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Holly K HuseDepartment of Pathology and Laboratory Medicine, Harbor-UCLA Medical Center, Torrance, California, USA.
Mark J LeeDepartment of Pathology and Clinical Microbiology Laboratory, Duke University School of Medicine, Durham, North Carolina, USA.
Mandy WoottonSpecialist Antimicrobial Chemotherapy Unit, Public Health Wales, University Hospital of Wales, Cardiff, United Kingdom.
Susan E SharpCopan Diagnostics, Murrieta, California, USA.
Maria TraczewskiClinical Microbiology Institute, Inc., Wilsonville, Oregon, USA.
John J LiPumaDepartment of Pediatrics, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0003-4033-7794
Peter JorthDepartment of Pathology and Laboratory Medicine, Medicine, and Biomedical Sciences, Cedars-Sinai Medical Centergrid.50956.3f, Los Angeles, California, USA.ORCID 0000-0002-0981-740X

Funding

Determining mechanisms and prevalence of virulence-enhancing resistance mutationsK22AI127473 · NIAID · CEDARS-SINAI MEDICAL CENTER · PI JORTH, PETER ALLAN · 2018 to 2019
$268k
NIAID NIH HHS K22 AI127473NIAID NIH HHS K22AI127473
6 · The paper itself

Abstract

The Burkholderia cepacia complex (BCC) is known for causing serious lung infections in people with cystic fibrosis (CF). These infections can require lung transplantation, eligibility for which may be guided by antimicrobial susceptibility testing (AST). While the Clinical and Laboratory Standards Institute recommends AST for BCC, the European Committee on Antimicrobial Susceptibility Testing (EUCAST) does not, due to poor method performance and correlation with clinical outcomes. Furthermore, limited data exist on the performance of automated AST methods for BCC. To address these issues, reproducibility and accuracy were evaluated for disk diffusion (DD), broth microdilution (BMD), and MicroScan WalkAway using 50 B. cenocepacia and 50

Indexed as

Burkholderia cenocepaciaBurkholderia cepacia complexBurkholderia InfectionsCystic FibrosisAnti-Bacterial AgentsBurkholderiaHumansMicrobial Sensitivity TestsReproducibility of ResultsAnti-Bacterial Agentsantimicrobial agentsBurkholderiacystic fibrosissusceptibility testing

Identifiers

PMID34524889
PMCPMC8601252

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.